Heterogeneity induced GZMA-F2R communication inefficient impairs antitumor immunotherapy of PD-1 mAb through JAK2/STAT1 signal suppression in hepatocellular carcinoma

Tumor heterogeneity has been associated with immunotherapy and targeted drug resistance in hepatocellular carcinoma (HCC). However, communications between tumor and cytotoxic cells are poorly understood to date. In the present study, thirty-one clusters of cells were discovered in the tumor tissues...

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Detalles Bibliográficos
Autores principales: Gao, Yuxue, Xu, Qingguo, Li, Xinqiang, Guo, Yuan, Zhang, Bowen, Jin, Yan, zhu, Cunle, Shen, Yuntai, Yang, Pengxiang, Shi, Ying, Jin, Rifeng, Liu, Daojie, Ouyang, Yabo, Liu, Xiaoni, Wang, Wenjing, Chen, Dexi, Yang, Tongwang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901912/
https://www.ncbi.nlm.nih.gov/pubmed/35256589
http://dx.doi.org/10.1038/s41419-022-04654-7

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