Structural derivatization strategies of natural phenols by semi-synthesis and total-synthesis

Structural derivatization of natural products has been a continuing and irreplaceable source of novel drug leads. Natural phenols are a broad category of natural products with wide pharmacological activity and have offered plenty of clinical drugs. However, the structural complexity and wide variety...

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Autores principales: Lin, Ding, Jiang, Senze, Zhang, Ailian, Wu, Tong, Qian, Yongchang, Shao, Qingsong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901917/
https://www.ncbi.nlm.nih.gov/pubmed/35254538
http://dx.doi.org/10.1007/s13659-022-00331-6
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author Lin, Ding
Jiang, Senze
Zhang, Ailian
Wu, Tong
Qian, Yongchang
Shao, Qingsong
author_facet Lin, Ding
Jiang, Senze
Zhang, Ailian
Wu, Tong
Qian, Yongchang
Shao, Qingsong
author_sort Lin, Ding
collection PubMed
description Structural derivatization of natural products has been a continuing and irreplaceable source of novel drug leads. Natural phenols are a broad category of natural products with wide pharmacological activity and have offered plenty of clinical drugs. However, the structural complexity and wide variety of natural phenols leads to the difficulty of structural derivatization. Skeleton analysis indicated most types of natural phenols can be structured by the combination and extension of three common fragments containing phenol, phenylpropanoid and benzoyl. Based on these fragments, the derivatization strategies of natural phenols were unified and comprehensively analyzed in this review. In addition to classical methods, advanced strategies with high selectivity, efficiency and practicality were emphasized. Total synthesis strategies of typical fragments such as stilbenes, chalcones and flavonoids were also covered and analyzed as the supplementary for supporting the diversity-oriented derivatization of natural phenols.
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spelling pubmed-89019172022-03-15 Structural derivatization strategies of natural phenols by semi-synthesis and total-synthesis Lin, Ding Jiang, Senze Zhang, Ailian Wu, Tong Qian, Yongchang Shao, Qingsong Nat Prod Bioprospect Review Structural derivatization of natural products has been a continuing and irreplaceable source of novel drug leads. Natural phenols are a broad category of natural products with wide pharmacological activity and have offered plenty of clinical drugs. However, the structural complexity and wide variety of natural phenols leads to the difficulty of structural derivatization. Skeleton analysis indicated most types of natural phenols can be structured by the combination and extension of three common fragments containing phenol, phenylpropanoid and benzoyl. Based on these fragments, the derivatization strategies of natural phenols were unified and comprehensively analyzed in this review. In addition to classical methods, advanced strategies with high selectivity, efficiency and practicality were emphasized. Total synthesis strategies of typical fragments such as stilbenes, chalcones and flavonoids were also covered and analyzed as the supplementary for supporting the diversity-oriented derivatization of natural phenols. Springer Singapore 2022-03-07 /pmc/articles/PMC8901917/ /pubmed/35254538 http://dx.doi.org/10.1007/s13659-022-00331-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Lin, Ding
Jiang, Senze
Zhang, Ailian
Wu, Tong
Qian, Yongchang
Shao, Qingsong
Structural derivatization strategies of natural phenols by semi-synthesis and total-synthesis
title Structural derivatization strategies of natural phenols by semi-synthesis and total-synthesis
title_full Structural derivatization strategies of natural phenols by semi-synthesis and total-synthesis
title_fullStr Structural derivatization strategies of natural phenols by semi-synthesis and total-synthesis
title_full_unstemmed Structural derivatization strategies of natural phenols by semi-synthesis and total-synthesis
title_short Structural derivatization strategies of natural phenols by semi-synthesis and total-synthesis
title_sort structural derivatization strategies of natural phenols by semi-synthesis and total-synthesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901917/
https://www.ncbi.nlm.nih.gov/pubmed/35254538
http://dx.doi.org/10.1007/s13659-022-00331-6
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