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Self-attenuating adenovirus enables production of recombinant adeno-associated virus for high manufacturing yield without contamination

Recombinant adeno-associated virus (rAAV) shows great promise for gene therapy, however scalability, yield and quality remain significant issues. Here we describe an rAAV manufacturing strategy using a ‘helper’ adenovirus that self-inhibits its major late promoter (MLP) to truncate its own replicati...

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Detalles Bibliográficos
Autores principales:	Su, Weiheng, Patrício, Maria I., Duffy, Margaret R., Krakowiak, Jakub M., Seymour, Leonard W., Cawood, Ryan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901928/ https://www.ncbi.nlm.nih.gov/pubmed/35256603 http://dx.doi.org/10.1038/s41467-022-28738-2

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