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Promoting Plant-Based Therapies for Chronic Kidney Disease

Chronic kidney disease (CKD) is debilitating, increasing in incidence worldwide, and a financial and social burden on health systems. Kidney failure, the final stage of CKD, is life-threatening if untreated with kidney replacement therapies. Current therapies using commercially-available drugs, such...

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Autores principales: Khan, Muhammad Ali, Kassianos, Andrew J, Hoy, Wendy E, Alam, AHM Khurshid, Healy, Helen G, Gobe, Glenda C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8902019/
https://www.ncbi.nlm.nih.gov/pubmed/35243916
http://dx.doi.org/10.1177/2515690X221079688
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author Khan, Muhammad Ali
Kassianos, Andrew J
Hoy, Wendy E
Alam, AHM Khurshid
Healy, Helen G
Gobe, Glenda C
author_facet Khan, Muhammad Ali
Kassianos, Andrew J
Hoy, Wendy E
Alam, AHM Khurshid
Healy, Helen G
Gobe, Glenda C
author_sort Khan, Muhammad Ali
collection PubMed
description Chronic kidney disease (CKD) is debilitating, increasing in incidence worldwide, and a financial and social burden on health systems. Kidney failure, the final stage of CKD, is life-threatening if untreated with kidney replacement therapies. Current therapies using commercially-available drugs, such as angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers and calcium channel blockers, generally only delay the progression of CKD. This review article focuses on effective alternative therapies to improve the prevention and treatment of CKD, using plants or plant extracts. Three mechanistic processes that are well-documented in CKD pathogenesis are inflammation, fibrosis, and oxidative stress. Many plants and their extracts are already known to ameliorate kidney dysfunction through antioxidant action, with subsequent benefits on inflammation and fibrosis. In vitro and in vivo experiments using plant-based therapies for pre-clinical research demonstrate some robust therapeutic benefits. In the CKD clinic, combination treatments of plant extracts with conventional therapies that are seen as relatively successful currently may confer additive or synergistic renoprotective effects. Therefore, the aim of recent research is to identify, rigorously test pre-clinically and clinically, and avoid any toxic outcomes to obtain optimal therapeutic benefit from medicinal plants. This review may prove to be a filtering tool to researchers into complementary and alternative medicines to find out the current trends of using plant-based therapies for the treatment of kidney diseases, including CKD.
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spelling pubmed-89020192022-03-09 Promoting Plant-Based Therapies for Chronic Kidney Disease Khan, Muhammad Ali Kassianos, Andrew J Hoy, Wendy E Alam, AHM Khurshid Healy, Helen G Gobe, Glenda C J Evid Based Integr Med Topical Review Article Chronic kidney disease (CKD) is debilitating, increasing in incidence worldwide, and a financial and social burden on health systems. Kidney failure, the final stage of CKD, is life-threatening if untreated with kidney replacement therapies. Current therapies using commercially-available drugs, such as angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers and calcium channel blockers, generally only delay the progression of CKD. This review article focuses on effective alternative therapies to improve the prevention and treatment of CKD, using plants or plant extracts. Three mechanistic processes that are well-documented in CKD pathogenesis are inflammation, fibrosis, and oxidative stress. Many plants and their extracts are already known to ameliorate kidney dysfunction through antioxidant action, with subsequent benefits on inflammation and fibrosis. In vitro and in vivo experiments using plant-based therapies for pre-clinical research demonstrate some robust therapeutic benefits. In the CKD clinic, combination treatments of plant extracts with conventional therapies that are seen as relatively successful currently may confer additive or synergistic renoprotective effects. Therefore, the aim of recent research is to identify, rigorously test pre-clinically and clinically, and avoid any toxic outcomes to obtain optimal therapeutic benefit from medicinal plants. This review may prove to be a filtering tool to researchers into complementary and alternative medicines to find out the current trends of using plant-based therapies for the treatment of kidney diseases, including CKD. SAGE Publications 2022-03-04 /pmc/articles/PMC8902019/ /pubmed/35243916 http://dx.doi.org/10.1177/2515690X221079688 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Topical Review Article
Khan, Muhammad Ali
Kassianos, Andrew J
Hoy, Wendy E
Alam, AHM Khurshid
Healy, Helen G
Gobe, Glenda C
Promoting Plant-Based Therapies for Chronic Kidney Disease
title Promoting Plant-Based Therapies for Chronic Kidney Disease
title_full Promoting Plant-Based Therapies for Chronic Kidney Disease
title_fullStr Promoting Plant-Based Therapies for Chronic Kidney Disease
title_full_unstemmed Promoting Plant-Based Therapies for Chronic Kidney Disease
title_short Promoting Plant-Based Therapies for Chronic Kidney Disease
title_sort promoting plant-based therapies for chronic kidney disease
topic Topical Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8902019/
https://www.ncbi.nlm.nih.gov/pubmed/35243916
http://dx.doi.org/10.1177/2515690X221079688
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