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Promoting Plant-Based Therapies for Chronic Kidney Disease
Chronic kidney disease (CKD) is debilitating, increasing in incidence worldwide, and a financial and social burden on health systems. Kidney failure, the final stage of CKD, is life-threatening if untreated with kidney replacement therapies. Current therapies using commercially-available drugs, such...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8902019/ https://www.ncbi.nlm.nih.gov/pubmed/35243916 http://dx.doi.org/10.1177/2515690X221079688 |
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author | Khan, Muhammad Ali Kassianos, Andrew J Hoy, Wendy E Alam, AHM Khurshid Healy, Helen G Gobe, Glenda C |
author_facet | Khan, Muhammad Ali Kassianos, Andrew J Hoy, Wendy E Alam, AHM Khurshid Healy, Helen G Gobe, Glenda C |
author_sort | Khan, Muhammad Ali |
collection | PubMed |
description | Chronic kidney disease (CKD) is debilitating, increasing in incidence worldwide, and a financial and social burden on health systems. Kidney failure, the final stage of CKD, is life-threatening if untreated with kidney replacement therapies. Current therapies using commercially-available drugs, such as angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers and calcium channel blockers, generally only delay the progression of CKD. This review article focuses on effective alternative therapies to improve the prevention and treatment of CKD, using plants or plant extracts. Three mechanistic processes that are well-documented in CKD pathogenesis are inflammation, fibrosis, and oxidative stress. Many plants and their extracts are already known to ameliorate kidney dysfunction through antioxidant action, with subsequent benefits on inflammation and fibrosis. In vitro and in vivo experiments using plant-based therapies for pre-clinical research demonstrate some robust therapeutic benefits. In the CKD clinic, combination treatments of plant extracts with conventional therapies that are seen as relatively successful currently may confer additive or synergistic renoprotective effects. Therefore, the aim of recent research is to identify, rigorously test pre-clinically and clinically, and avoid any toxic outcomes to obtain optimal therapeutic benefit from medicinal plants. This review may prove to be a filtering tool to researchers into complementary and alternative medicines to find out the current trends of using plant-based therapies for the treatment of kidney diseases, including CKD. |
format | Online Article Text |
id | pubmed-8902019 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-89020192022-03-09 Promoting Plant-Based Therapies for Chronic Kidney Disease Khan, Muhammad Ali Kassianos, Andrew J Hoy, Wendy E Alam, AHM Khurshid Healy, Helen G Gobe, Glenda C J Evid Based Integr Med Topical Review Article Chronic kidney disease (CKD) is debilitating, increasing in incidence worldwide, and a financial and social burden on health systems. Kidney failure, the final stage of CKD, is life-threatening if untreated with kidney replacement therapies. Current therapies using commercially-available drugs, such as angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers and calcium channel blockers, generally only delay the progression of CKD. This review article focuses on effective alternative therapies to improve the prevention and treatment of CKD, using plants or plant extracts. Three mechanistic processes that are well-documented in CKD pathogenesis are inflammation, fibrosis, and oxidative stress. Many plants and their extracts are already known to ameliorate kidney dysfunction through antioxidant action, with subsequent benefits on inflammation and fibrosis. In vitro and in vivo experiments using plant-based therapies for pre-clinical research demonstrate some robust therapeutic benefits. In the CKD clinic, combination treatments of plant extracts with conventional therapies that are seen as relatively successful currently may confer additive or synergistic renoprotective effects. Therefore, the aim of recent research is to identify, rigorously test pre-clinically and clinically, and avoid any toxic outcomes to obtain optimal therapeutic benefit from medicinal plants. This review may prove to be a filtering tool to researchers into complementary and alternative medicines to find out the current trends of using plant-based therapies for the treatment of kidney diseases, including CKD. SAGE Publications 2022-03-04 /pmc/articles/PMC8902019/ /pubmed/35243916 http://dx.doi.org/10.1177/2515690X221079688 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Topical Review Article Khan, Muhammad Ali Kassianos, Andrew J Hoy, Wendy E Alam, AHM Khurshid Healy, Helen G Gobe, Glenda C Promoting Plant-Based Therapies for Chronic Kidney Disease |
title | Promoting Plant-Based Therapies for Chronic Kidney Disease |
title_full | Promoting Plant-Based Therapies for Chronic Kidney Disease |
title_fullStr | Promoting Plant-Based Therapies for Chronic Kidney Disease |
title_full_unstemmed | Promoting Plant-Based Therapies for Chronic Kidney Disease |
title_short | Promoting Plant-Based Therapies for Chronic Kidney Disease |
title_sort | promoting plant-based therapies for chronic kidney disease |
topic | Topical Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8902019/ https://www.ncbi.nlm.nih.gov/pubmed/35243916 http://dx.doi.org/10.1177/2515690X221079688 |
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