Analysis of capecitabine metabolites in conjunction with digital autoradiography in a murine model of pancreatic cancer suggests extensive drug penetration through the tumor

Previously published digital autoradiography of (3)H‐labeled capecitabine reveals a near‐uniform distribution of activity throughout a murine pancreatic model. This is in contrast both to (14)C‐labeled gemcitabine, and established expectations, as the dense stroma of pancreatic cancer is understood...

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Detalles Bibliográficos
Autores principales: Russell, James, Fanchon, Louise, Alwaseem, Hanan, Molina, Henrik, O’Donoghue, Isabella, Bahr, Amber, de Stanchina, Elisa, Pillarsetty, Nagavarakishore, Humm, John L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8902142/
https://www.ncbi.nlm.nih.gov/pubmed/35257504
http://dx.doi.org/10.1002/prp2.898

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