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Diabetes mellitus and the causes of hospitalisation in people with heart failure
INTRODUCTION: Diabetes mellitus (DM) is associated with increased risk of hospitalisation in people with heart failure and reduced ejection fraction (HFrEF). However, little is known about the causes of these events. METHODS: Prospective cohort study of 711 people with stable HFrEF. Hospitalisations...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8902201/ https://www.ncbi.nlm.nih.gov/pubmed/35236158 http://dx.doi.org/10.1177/14791641211073943 |
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author | Malik, Anam Garland, Ellis Drozd, Michael Palin, Victoria Giannoudi, Marilena Straw, Sam Jex, Nick Walker, Andrew MN Gierula, John Paton, Maria Witte, Klaus K Kearney, Mark T Levelt, Eylem Cubbon, Richard M |
author_facet | Malik, Anam Garland, Ellis Drozd, Michael Palin, Victoria Giannoudi, Marilena Straw, Sam Jex, Nick Walker, Andrew MN Gierula, John Paton, Maria Witte, Klaus K Kearney, Mark T Levelt, Eylem Cubbon, Richard M |
author_sort | Malik, Anam |
collection | PubMed |
description | INTRODUCTION: Diabetes mellitus (DM) is associated with increased risk of hospitalisation in people with heart failure and reduced ejection fraction (HFrEF). However, little is known about the causes of these events. METHODS: Prospective cohort study of 711 people with stable HFrEF. Hospitalisations were categorised by cause as: decompensated heart failure; other cardiovascular; infection or other non-cardiovascular. Rates of hospitalisation and burden of hospitalisation (percentage of follow-up time in hospital) were compared in people with and without DM. RESULTS: After a mean follow-up of 4.0 years, 1568 hospitalisations occurred in the entire cohort. DM (present in 32% [n=224]) was associated with a higher rate (mean 1.07 vs 0.78 per 100 patient-years; p<0.001) and burden (3.4 vs 2.2% of follow-up time; p<0.001) of hospitalisation. Cause-specific analyses revealed increased rate and burden of hospitalisation due to decompensated heart failure, other cardiovascular causes and infection in people with DM, whereas other non-cardiovascular causes were comparable. Infection made the largest contribution to the burden of hospitalisation in people with and without DM. CONCLUSIONS: In people with HFrEF, DM is associated with a greater burden of hospitalisation due to decompensated heart failure, other cardiovascular events and infection, with infection making the largest contribution. |
format | Online Article Text |
id | pubmed-8902201 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-89022012022-03-09 Diabetes mellitus and the causes of hospitalisation in people with heart failure Malik, Anam Garland, Ellis Drozd, Michael Palin, Victoria Giannoudi, Marilena Straw, Sam Jex, Nick Walker, Andrew MN Gierula, John Paton, Maria Witte, Klaus K Kearney, Mark T Levelt, Eylem Cubbon, Richard M Diab Vasc Dis Res Original Article INTRODUCTION: Diabetes mellitus (DM) is associated with increased risk of hospitalisation in people with heart failure and reduced ejection fraction (HFrEF). However, little is known about the causes of these events. METHODS: Prospective cohort study of 711 people with stable HFrEF. Hospitalisations were categorised by cause as: decompensated heart failure; other cardiovascular; infection or other non-cardiovascular. Rates of hospitalisation and burden of hospitalisation (percentage of follow-up time in hospital) were compared in people with and without DM. RESULTS: After a mean follow-up of 4.0 years, 1568 hospitalisations occurred in the entire cohort. DM (present in 32% [n=224]) was associated with a higher rate (mean 1.07 vs 0.78 per 100 patient-years; p<0.001) and burden (3.4 vs 2.2% of follow-up time; p<0.001) of hospitalisation. Cause-specific analyses revealed increased rate and burden of hospitalisation due to decompensated heart failure, other cardiovascular causes and infection in people with DM, whereas other non-cardiovascular causes were comparable. Infection made the largest contribution to the burden of hospitalisation in people with and without DM. CONCLUSIONS: In people with HFrEF, DM is associated with a greater burden of hospitalisation due to decompensated heart failure, other cardiovascular events and infection, with infection making the largest contribution. SAGE Publications 2022-03-02 /pmc/articles/PMC8902201/ /pubmed/35236158 http://dx.doi.org/10.1177/14791641211073943 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Article Malik, Anam Garland, Ellis Drozd, Michael Palin, Victoria Giannoudi, Marilena Straw, Sam Jex, Nick Walker, Andrew MN Gierula, John Paton, Maria Witte, Klaus K Kearney, Mark T Levelt, Eylem Cubbon, Richard M Diabetes mellitus and the causes of hospitalisation in people with heart failure |
title | Diabetes mellitus and the causes of hospitalisation in people with
heart failure |
title_full | Diabetes mellitus and the causes of hospitalisation in people with
heart failure |
title_fullStr | Diabetes mellitus and the causes of hospitalisation in people with
heart failure |
title_full_unstemmed | Diabetes mellitus and the causes of hospitalisation in people with
heart failure |
title_short | Diabetes mellitus and the causes of hospitalisation in people with
heart failure |
title_sort | diabetes mellitus and the causes of hospitalisation in people with
heart failure |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8902201/ https://www.ncbi.nlm.nih.gov/pubmed/35236158 http://dx.doi.org/10.1177/14791641211073943 |
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