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Polymeric Systems for Cancer Immunotherapy: A Review

Immunotherapy holds enormous promise to create a new outlook of cancer therapy by eliminating tumors via activation of the immune system. In immunotherapy, polymeric systems play a significant role in improving antitumor efficacy and safety profile. Polymeric systems possess many favorable propertie...

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Autores principales: Le, Thai Minh Duy, Yoon, A-Rum, Thambi, Thavasyappan, Yun, Chae-Ok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8902250/
https://www.ncbi.nlm.nih.gov/pubmed/35273607
http://dx.doi.org/10.3389/fimmu.2022.826876
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author Le, Thai Minh Duy
Yoon, A-Rum
Thambi, Thavasyappan
Yun, Chae-Ok
author_facet Le, Thai Minh Duy
Yoon, A-Rum
Thambi, Thavasyappan
Yun, Chae-Ok
author_sort Le, Thai Minh Duy
collection PubMed
description Immunotherapy holds enormous promise to create a new outlook of cancer therapy by eliminating tumors via activation of the immune system. In immunotherapy, polymeric systems play a significant role in improving antitumor efficacy and safety profile. Polymeric systems possess many favorable properties, including magnificent biocompatibility and biodegradability, structural and component diversity, easy and controllable fabrication, and high loading capacity for immune-related substances. These properties allow polymeric systems to perform multiple functions in immunotherapy, such as immune stimulants, modifying and activating T cells, delivery system for immune cargos, or as an artificial antigen-presenting cell. Among diverse immunotherapies, immune checkpoint inhibitors, chimeric antigen receptor (CAR) T cell, and oncolytic virus recently have been dramatically investigated for their remarkable success in clinical trials. In this report, we review the monotherapy status of immune checkpoint inhibitors, CAR-T cell, and oncolytic virus, and their current combination strategies with diverse polymeric systems.
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spelling pubmed-89022502022-03-09 Polymeric Systems for Cancer Immunotherapy: A Review Le, Thai Minh Duy Yoon, A-Rum Thambi, Thavasyappan Yun, Chae-Ok Front Immunol Immunology Immunotherapy holds enormous promise to create a new outlook of cancer therapy by eliminating tumors via activation of the immune system. In immunotherapy, polymeric systems play a significant role in improving antitumor efficacy and safety profile. Polymeric systems possess many favorable properties, including magnificent biocompatibility and biodegradability, structural and component diversity, easy and controllable fabrication, and high loading capacity for immune-related substances. These properties allow polymeric systems to perform multiple functions in immunotherapy, such as immune stimulants, modifying and activating T cells, delivery system for immune cargos, or as an artificial antigen-presenting cell. Among diverse immunotherapies, immune checkpoint inhibitors, chimeric antigen receptor (CAR) T cell, and oncolytic virus recently have been dramatically investigated for their remarkable success in clinical trials. In this report, we review the monotherapy status of immune checkpoint inhibitors, CAR-T cell, and oncolytic virus, and their current combination strategies with diverse polymeric systems. Frontiers Media S.A. 2022-02-22 /pmc/articles/PMC8902250/ /pubmed/35273607 http://dx.doi.org/10.3389/fimmu.2022.826876 Text en Copyright © 2022 Le, Yoon, Thambi and Yun https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Le, Thai Minh Duy
Yoon, A-Rum
Thambi, Thavasyappan
Yun, Chae-Ok
Polymeric Systems for Cancer Immunotherapy: A Review
title Polymeric Systems for Cancer Immunotherapy: A Review
title_full Polymeric Systems for Cancer Immunotherapy: A Review
title_fullStr Polymeric Systems for Cancer Immunotherapy: A Review
title_full_unstemmed Polymeric Systems for Cancer Immunotherapy: A Review
title_short Polymeric Systems for Cancer Immunotherapy: A Review
title_sort polymeric systems for cancer immunotherapy: a review
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8902250/
https://www.ncbi.nlm.nih.gov/pubmed/35273607
http://dx.doi.org/10.3389/fimmu.2022.826876
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