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Case of subcutaneous insulin resistance syndrome treated with ultra‐rapid insulin lispro

Subcutaneous insulin resistance syndrome is a rare condition that causes difficulty in glycemic control due to severe resistance to subcutaneous insulin injections. We herein present a case of a 40‐year‐old woman with type 2 diabetes mellitus who had been diagnosed with subcutaneous insulin resistan...

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Detalles Bibliográficos
Autores principales: Ishii, Takahiro, Katayama, Akihiro, Sue, Mihiro, Kuribayashi, Remi, Tenta, Masafumi, Matsushita, Yuichi, Takeda, Masaya, Iseda, Izumi, Tani, Satomi, Hida, Kazuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8902381/
https://www.ncbi.nlm.nih.gov/pubmed/34510782
http://dx.doi.org/10.1111/jdi.13667
Descripción
Sumario:Subcutaneous insulin resistance syndrome is a rare condition that causes difficulty in glycemic control due to severe resistance to subcutaneous insulin injections. We herein present a case of a 40‐year‐old woman with type 2 diabetes mellitus who had been diagnosed with subcutaneous insulin resistance syndrome since the age of 29 years, and had been persistently treated with continuous subcutaneous insulin infusion using a mixture of insulin lispro and heparin. The patient was switched from insulin lispro plus heparin to ultra‐rapid insulin lispro; given that it contains treprostinil and citrate, it is expected to have similar effects as heparin, and shows similar glucose‐lowering effects and insulin absorption. Our results suggest that treatment with ultra‐rapid insulin lispro is effective for subcutaneous insulin resistance syndrome.