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Clinicopathological features of non-conventional renal cell carcinoma histological subtypes: Learning points from a large contemporary series spanning over three decades

PURPOSE: To perform a retrospective review of the clinicopathological features of patients with conventional and non-conventional renal cell carcinoma (cRCC and ncRCC). MATERIALS AND METHODS: A large prospectively maintained uro-oncological registry was accessed to extract clinicopathological data o...

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Autores principales: Lim, Ee Jean, Fong, Khi Yung, Li, Jingqiu, Huang, Hong Hong, Chen, Kenneth, Tay, Kae Jack, Cheng, Christopher Wai Sam, Ho, Henry Sun Sien, Ngo, Nye Thane, Yuen, John Shyi Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Urological Association 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8902431/
https://www.ncbi.nlm.nih.gov/pubmed/35244988
http://dx.doi.org/10.4111/icu.20210373
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author Lim, Ee Jean
Fong, Khi Yung
Li, Jingqiu
Huang, Hong Hong
Chen, Kenneth
Tay, Kae Jack
Cheng, Christopher Wai Sam
Ho, Henry Sun Sien
Ngo, Nye Thane
Yuen, John Shyi Peng
author_facet Lim, Ee Jean
Fong, Khi Yung
Li, Jingqiu
Huang, Hong Hong
Chen, Kenneth
Tay, Kae Jack
Cheng, Christopher Wai Sam
Ho, Henry Sun Sien
Ngo, Nye Thane
Yuen, John Shyi Peng
author_sort Lim, Ee Jean
collection PubMed
description PURPOSE: To perform a retrospective review of the clinicopathological features of patients with conventional and non-conventional renal cell carcinoma (cRCC and ncRCC). MATERIALS AND METHODS: A large prospectively maintained uro-oncological registry was accessed to extract clinicopathological data of patients diagnosed with renal tumors who subsequently underwent nephrectomy from 1990–2019. Demographics and operative parameters were extracted. Analyses of overall survival (OS) and cancer-specific survival (CSS) were performed using the Kaplan–Meier method. Cox proportional-hazards analysis was used to identify risk factors which influenced survival. RESULTS: There were a total of 1,686 consecutive nephrectomies which was retrieved, with 1,286 cRCC and 400 ncRCC. The commonest ncRCC subtypes were papillary (n=198, 11.7%), clear cell papillary (n=50, 3.0%) and chromophobe (n=49, 2.9%) RCC. Kaplan–Meier estimates of OS were higher in cRCC (0.74; 95% confidence interval [CI], 0.71–0.78) than ncRCC (hazard ratio, 1.47; 95% CI, 1.16–1.87). Among individual subtypes, chromophobe RCC had the highest 5-year OS (0.90; 95% CI, 0.79–1.0). Among ncRCC subtypes, acquired cystic RCC demonstrated the highest association with end-stage renal failure and hypertension, with the highest CSS. MiT family translocation RCC had the youngest mean age at presentation (45.6±12.8 y) and excellent CSS. Factors associated with increased OS in the entire cohort included shorter operative time, partial nephrectomy and lower tumor stages. CONCLUSIONS: This study provides a comprehensive contemporary overview of ncRCCs which are yet poorly characterized, in comparison to cRCCs. Data from this study would contribute towards tailored patient counseling and healthcare resource planning.
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spelling pubmed-89024312022-03-16 Clinicopathological features of non-conventional renal cell carcinoma histological subtypes: Learning points from a large contemporary series spanning over three decades Lim, Ee Jean Fong, Khi Yung Li, Jingqiu Huang, Hong Hong Chen, Kenneth Tay, Kae Jack Cheng, Christopher Wai Sam Ho, Henry Sun Sien Ngo, Nye Thane Yuen, John Shyi Peng Investig Clin Urol Original Article PURPOSE: To perform a retrospective review of the clinicopathological features of patients with conventional and non-conventional renal cell carcinoma (cRCC and ncRCC). MATERIALS AND METHODS: A large prospectively maintained uro-oncological registry was accessed to extract clinicopathological data of patients diagnosed with renal tumors who subsequently underwent nephrectomy from 1990–2019. Demographics and operative parameters were extracted. Analyses of overall survival (OS) and cancer-specific survival (CSS) were performed using the Kaplan–Meier method. Cox proportional-hazards analysis was used to identify risk factors which influenced survival. RESULTS: There were a total of 1,686 consecutive nephrectomies which was retrieved, with 1,286 cRCC and 400 ncRCC. The commonest ncRCC subtypes were papillary (n=198, 11.7%), clear cell papillary (n=50, 3.0%) and chromophobe (n=49, 2.9%) RCC. Kaplan–Meier estimates of OS were higher in cRCC (0.74; 95% confidence interval [CI], 0.71–0.78) than ncRCC (hazard ratio, 1.47; 95% CI, 1.16–1.87). Among individual subtypes, chromophobe RCC had the highest 5-year OS (0.90; 95% CI, 0.79–1.0). Among ncRCC subtypes, acquired cystic RCC demonstrated the highest association with end-stage renal failure and hypertension, with the highest CSS. MiT family translocation RCC had the youngest mean age at presentation (45.6±12.8 y) and excellent CSS. Factors associated with increased OS in the entire cohort included shorter operative time, partial nephrectomy and lower tumor stages. CONCLUSIONS: This study provides a comprehensive contemporary overview of ncRCCs which are yet poorly characterized, in comparison to cRCCs. Data from this study would contribute towards tailored patient counseling and healthcare resource planning. The Korean Urological Association 2022-03 2022-02-28 /pmc/articles/PMC8902431/ /pubmed/35244988 http://dx.doi.org/10.4111/icu.20210373 Text en © The Korean Urological Association https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Lim, Ee Jean
Fong, Khi Yung
Li, Jingqiu
Huang, Hong Hong
Chen, Kenneth
Tay, Kae Jack
Cheng, Christopher Wai Sam
Ho, Henry Sun Sien
Ngo, Nye Thane
Yuen, John Shyi Peng
Clinicopathological features of non-conventional renal cell carcinoma histological subtypes: Learning points from a large contemporary series spanning over three decades
title Clinicopathological features of non-conventional renal cell carcinoma histological subtypes: Learning points from a large contemporary series spanning over three decades
title_full Clinicopathological features of non-conventional renal cell carcinoma histological subtypes: Learning points from a large contemporary series spanning over three decades
title_fullStr Clinicopathological features of non-conventional renal cell carcinoma histological subtypes: Learning points from a large contemporary series spanning over three decades
title_full_unstemmed Clinicopathological features of non-conventional renal cell carcinoma histological subtypes: Learning points from a large contemporary series spanning over three decades
title_short Clinicopathological features of non-conventional renal cell carcinoma histological subtypes: Learning points from a large contemporary series spanning over three decades
title_sort clinicopathological features of non-conventional renal cell carcinoma histological subtypes: learning points from a large contemporary series spanning over three decades
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8902431/
https://www.ncbi.nlm.nih.gov/pubmed/35244988
http://dx.doi.org/10.4111/icu.20210373
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