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Clinicopathological features of non-conventional renal cell carcinoma histological subtypes: Learning points from a large contemporary series spanning over three decades
PURPOSE: To perform a retrospective review of the clinicopathological features of patients with conventional and non-conventional renal cell carcinoma (cRCC and ncRCC). MATERIALS AND METHODS: A large prospectively maintained uro-oncological registry was accessed to extract clinicopathological data o...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Urological Association
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8902431/ https://www.ncbi.nlm.nih.gov/pubmed/35244988 http://dx.doi.org/10.4111/icu.20210373 |
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author | Lim, Ee Jean Fong, Khi Yung Li, Jingqiu Huang, Hong Hong Chen, Kenneth Tay, Kae Jack Cheng, Christopher Wai Sam Ho, Henry Sun Sien Ngo, Nye Thane Yuen, John Shyi Peng |
author_facet | Lim, Ee Jean Fong, Khi Yung Li, Jingqiu Huang, Hong Hong Chen, Kenneth Tay, Kae Jack Cheng, Christopher Wai Sam Ho, Henry Sun Sien Ngo, Nye Thane Yuen, John Shyi Peng |
author_sort | Lim, Ee Jean |
collection | PubMed |
description | PURPOSE: To perform a retrospective review of the clinicopathological features of patients with conventional and non-conventional renal cell carcinoma (cRCC and ncRCC). MATERIALS AND METHODS: A large prospectively maintained uro-oncological registry was accessed to extract clinicopathological data of patients diagnosed with renal tumors who subsequently underwent nephrectomy from 1990–2019. Demographics and operative parameters were extracted. Analyses of overall survival (OS) and cancer-specific survival (CSS) were performed using the Kaplan–Meier method. Cox proportional-hazards analysis was used to identify risk factors which influenced survival. RESULTS: There were a total of 1,686 consecutive nephrectomies which was retrieved, with 1,286 cRCC and 400 ncRCC. The commonest ncRCC subtypes were papillary (n=198, 11.7%), clear cell papillary (n=50, 3.0%) and chromophobe (n=49, 2.9%) RCC. Kaplan–Meier estimates of OS were higher in cRCC (0.74; 95% confidence interval [CI], 0.71–0.78) than ncRCC (hazard ratio, 1.47; 95% CI, 1.16–1.87). Among individual subtypes, chromophobe RCC had the highest 5-year OS (0.90; 95% CI, 0.79–1.0). Among ncRCC subtypes, acquired cystic RCC demonstrated the highest association with end-stage renal failure and hypertension, with the highest CSS. MiT family translocation RCC had the youngest mean age at presentation (45.6±12.8 y) and excellent CSS. Factors associated with increased OS in the entire cohort included shorter operative time, partial nephrectomy and lower tumor stages. CONCLUSIONS: This study provides a comprehensive contemporary overview of ncRCCs which are yet poorly characterized, in comparison to cRCCs. Data from this study would contribute towards tailored patient counseling and healthcare resource planning. |
format | Online Article Text |
id | pubmed-8902431 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Korean Urological Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-89024312022-03-16 Clinicopathological features of non-conventional renal cell carcinoma histological subtypes: Learning points from a large contemporary series spanning over three decades Lim, Ee Jean Fong, Khi Yung Li, Jingqiu Huang, Hong Hong Chen, Kenneth Tay, Kae Jack Cheng, Christopher Wai Sam Ho, Henry Sun Sien Ngo, Nye Thane Yuen, John Shyi Peng Investig Clin Urol Original Article PURPOSE: To perform a retrospective review of the clinicopathological features of patients with conventional and non-conventional renal cell carcinoma (cRCC and ncRCC). MATERIALS AND METHODS: A large prospectively maintained uro-oncological registry was accessed to extract clinicopathological data of patients diagnosed with renal tumors who subsequently underwent nephrectomy from 1990–2019. Demographics and operative parameters were extracted. Analyses of overall survival (OS) and cancer-specific survival (CSS) were performed using the Kaplan–Meier method. Cox proportional-hazards analysis was used to identify risk factors which influenced survival. RESULTS: There were a total of 1,686 consecutive nephrectomies which was retrieved, with 1,286 cRCC and 400 ncRCC. The commonest ncRCC subtypes were papillary (n=198, 11.7%), clear cell papillary (n=50, 3.0%) and chromophobe (n=49, 2.9%) RCC. Kaplan–Meier estimates of OS were higher in cRCC (0.74; 95% confidence interval [CI], 0.71–0.78) than ncRCC (hazard ratio, 1.47; 95% CI, 1.16–1.87). Among individual subtypes, chromophobe RCC had the highest 5-year OS (0.90; 95% CI, 0.79–1.0). Among ncRCC subtypes, acquired cystic RCC demonstrated the highest association with end-stage renal failure and hypertension, with the highest CSS. MiT family translocation RCC had the youngest mean age at presentation (45.6±12.8 y) and excellent CSS. Factors associated with increased OS in the entire cohort included shorter operative time, partial nephrectomy and lower tumor stages. CONCLUSIONS: This study provides a comprehensive contemporary overview of ncRCCs which are yet poorly characterized, in comparison to cRCCs. Data from this study would contribute towards tailored patient counseling and healthcare resource planning. The Korean Urological Association 2022-03 2022-02-28 /pmc/articles/PMC8902431/ /pubmed/35244988 http://dx.doi.org/10.4111/icu.20210373 Text en © The Korean Urological Association https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Lim, Ee Jean Fong, Khi Yung Li, Jingqiu Huang, Hong Hong Chen, Kenneth Tay, Kae Jack Cheng, Christopher Wai Sam Ho, Henry Sun Sien Ngo, Nye Thane Yuen, John Shyi Peng Clinicopathological features of non-conventional renal cell carcinoma histological subtypes: Learning points from a large contemporary series spanning over three decades |
title | Clinicopathological features of non-conventional renal cell carcinoma histological subtypes: Learning points from a large contemporary series spanning over three decades |
title_full | Clinicopathological features of non-conventional renal cell carcinoma histological subtypes: Learning points from a large contemporary series spanning over three decades |
title_fullStr | Clinicopathological features of non-conventional renal cell carcinoma histological subtypes: Learning points from a large contemporary series spanning over three decades |
title_full_unstemmed | Clinicopathological features of non-conventional renal cell carcinoma histological subtypes: Learning points from a large contemporary series spanning over three decades |
title_short | Clinicopathological features of non-conventional renal cell carcinoma histological subtypes: Learning points from a large contemporary series spanning over three decades |
title_sort | clinicopathological features of non-conventional renal cell carcinoma histological subtypes: learning points from a large contemporary series spanning over three decades |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8902431/ https://www.ncbi.nlm.nih.gov/pubmed/35244988 http://dx.doi.org/10.4111/icu.20210373 |
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