Cargando…

Gallic Acid Hindered Lung Cancer Progression by Inducing Cell Cycle Arrest and Apoptosis in A549 Lung Cancer Cells via PI3K/Akt Pathway

This study elucidates the anti-cancer potential of gallic acid (GA) as a promising therapeutic agent that exerts its effect by regulating the PI3K/Akt pathway. To prove our research rationale, we used diverse experimental methods such as cell viability assay, colony formation assay, tumor spheroid f...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ko, Eul-Bee, Jang, Yin-Gi, Kim, Cho-Won, Go, Ryeo-Eun, Lee, Hong Kyu, Choi, Kyung-Chul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Korean Society of Applied Pharmacology 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8902450/ https://www.ncbi.nlm.nih.gov/pubmed/34261818 http://dx.doi.org/10.4062/biomolther.2021.074

Ejemplares similares

Osthole induces G2/M arrest and apoptosis in lung cancer A549 cells by modulating PI3K/Akt pathway
por: Xu, Xiaoman, et al.
Publicado: (2011)

Anticancer property of gallic acid in A549, a human lung adenocarcinoma cell line, and possible mechanisms
por: Maurya, Dharmendra K., et al.
Publicado: (2011)

Regulation of angiogenic factors by the PI3K/Akt pathway in A549 lung cancer cells under hypoxic conditions
por: Xie, Youbang, et al.
Publicado: (2017)

Tetrazolium Violet Induced Apoptosis and Cell Cycle Arrest in Human Lung Cancer A549 Cells
por: Zhang, Xiao-Hong, et al.
Publicado: (2012)

Stellettin B Induces G1 Arrest, Apoptosis and Autophagy in Human Non-small Cell Lung Cancer A549 Cells via Blocking PI3K/Akt/mTOR Pathway
por: Wang, Ran, et al.
Publicado: (2016)

Lung cancer A549 cells suppressed with overexpressed HNF1B or PCDHA13 inhibited PI3K/AKT phosphorylation
por: Kang, Chunyan, et al.
Publicado: (2020)

Xanthohumol induces apoptosis and S phase cell cycle arrest in A549 non-small cell lung cancer cells
por: Yong, Wai Kuan, et al.
Publicado: (2015)

PTEN Inhibits Cell Proliferation, Promotes Cell Apoptosis, and Induces Cell Cycle Arrest via Downregulating the PI3K/AKT/hTERT Pathway in Lung Adenocarcinoma A549 Cells
por: Lu, Xiao-Xiao, et al.
Publicado: (2016)

A Novel Bromophenol Derivative BOS-102 Induces Cell Cycle Arrest and Apoptosis in Human A549 Lung Cancer Cells via ROS-Mediated PI3K/Akt and the MAPK Signaling Pathway
por: Guo, Chuan-Long, et al.
Publicado: (2018)

Polyphenols in Ilex latifolia Thunb. inhibit human lung cancer cell line A549 by regulation of the PI3K-Akt signaling pathway
por: Chen, Jing, et al.
Publicado: (2022)

Middle Infrared Radiation Induces G(2)/M Cell Cycle Arrest in A549 Lung Cancer Cells
por: Chang, Hsin-Yi, et al.
Publicado: (2013)

So-Cheong-Ryong-Tang induces apoptosis through activation of the intrinsic and extrinsic apoptosis pathways, and inhibition of the PI3K/Akt signaling pathway in non-small-cell lung cancer A549 cells
por: Park, Cheol, et al.
Publicado: (2015)

Bostrycin inhibits proliferation of human lung carcinoma A549 cells via downregulation of the PI3K/Akt pathway
por: Chen, Wei-Sheng, et al.
Publicado: (2011)

Silencing miR-21 Sensitizes Non-Small Cell Lung Cancer A549 Cells to Ionizing Radiation through Inhibition of PI3K/Akt
por: Ma, Yongfu, et al.
Publicado: (2014)

Tripchlorolide induces autophagy in lung cancer cells by inhibiting the PI3K/AKT/mTOR pathway and improves cisplatin sensitivity in A549/DDP cells
por: Chen, Li-Min, et al.
Publicado: (2017)

Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in A549 human lung cancer cells
por: Bai, Yang, et al.
Publicado: (2014)

Growth arrest and apoptosis via caspase activation of dioscoreanone in human non-small-cell lung cancer A549 cells
por: Hansakul, Pintusorn, et al.
Publicado: (2014)

Essential Oils of Lemongrass (Cymbopogon citratus Stapf) Induces Apoptosis and Cell Cycle Arrest in A549 Lung Cancer Cells
por: Trang, Duong Thu, et al.
Publicado: (2020)

Levobuipivacaine-Induced Dissemination of A549 Lung Cancer Cells
por: Chan, Shun-Ming, et al.
Publicado: (2017)

Effect of Sevoflurane on the Proliferation of A549 Lung Cancer Cells
por: Yun, Sangwon, et al.
Publicado: (2023)

Vitexin induces apoptosis through mitochondrial pathway and PI3K/Akt/mTOR signaling in human non-small cell lung cancer A549 cells
por: Liu, Xiaoli, et al.
Publicado: (2019)

Polyphyllin VII induces apoptotic cell death via inhibition of the PI3K/Akt and NF-κB pathways in A549 human lung cancer cells
por: He, Hao, et al.
Publicado: (2020)

ANTITUMOR AND APOPTOTIC EFFECTS OF CUCURBITACIN A IN A-549 LUNG CARCINOMA CELLS IS MEDIATED VIA G2/M CELL CYCLE ARREST AND M-TOR/PI3K/AKT SIGNALLING PATHWAY
por: Wang, Wen-dong, et al.
Publicado: (2017)

Flavonoids isolated from Citrus platymamma induced G2/M cell cycle arrest and apoptosis in A549 human lung cancer cells
por: Nagappan, Arulkumar, et al.
Publicado: (2016)

Synergistic Effect of Sulindac and Simvastatin on Apoptosis in Lung Cancer A549 Cells through AKT-Dependent Downregulation of Survivin
por: Kim, Young-Suk, et al.
Publicado: (2015)

Cytoplasm-localized SIRT1 downregulation attenuates apoptosis and cell cycle arrest in cisplatin-resistant lung cancer A549 cells
por: Yu, Hyeran, et al.
Publicado: (2020)

Tumor-associated macrophages affect the biological behavior of lung adenocarcinoma A549 cells through the PI3K/AKT signaling pathway
por: Yuan, Shiyang, et al.
Publicado: (2019)

Gene expression profiling of cancer stem cell in human lung adenocarcinoma A549 cells
por: Seo, Dong-Cheol, et al.
Publicado: (2007)

PVM/MA-shelled selol nanocapsules promote cell cycle arrest in A549 lung adenocarcinoma cells
por: de Souza, Ludmilla Regina, et al.
Publicado: (2014)

Exosomes: Decreased Sensitivity of Lung Cancer A549 Cells to Cisplatin
por: Xiao, Xia, et al.
Publicado: (2014)

Inhibitory role of puerarin on the A549 lung cancer cell line
por: Lang, Jie, et al.
Publicado: (2022)

Metformin Resistance Is Associated with Expression of Inflammatory and Invasive Genes in A549 Lung Cancer Cells
por: Seo, Dong Soo, et al.
Publicado: (2023)

Cediranib Induces Apoptosis, G1 Phase Cell Cycle Arrest, and Autophagy in Non-Small-Cell Lung Cancer Cell A549 In Vitro
por: Guo, Menghuan, et al.
Publicado: (2021)

Bauerane Induces S-Phase Cell Cycle Arrest, Apoptosis, and Inhibition of Proliferation of A549 Human Lung Cancer Cells Through the Phosphoinositide 3-Kinase (PI3K)/AKT and Signal Transducer and Activator of Transcription 3 (STAT3) Signaling Pathway
por: Chen, Qin, et al.
Publicado: (2020)

Eriodictyol exerts potent anticancer activity against A549 human lung cancer cell line by inducing mitochondrial-mediated apoptosis, G2/M cell cycle arrest and inhibition of m-TOR/PI3K/Akt signalling pathway
por: Zhang, Yong, et al.
Publicado: (2019)

Anti-cancer effects of 3,5-dimethylaminophenol in A549 lung cancer cells
por: Lin, Pei-Ying, et al.
Publicado: (2018)

Chloroquine increases the anti-cancer activity of epirubicin in A549 lung cancer cells
por: Liang, Ai-Ling, et al.
Publicado: (2020)

Molecular mechanisms underlying mangiferin-induced apoptosis and cell cycle arrest in A549 human lung carcinoma cells
por: SHI, WEI, et al.
Publicado: (2016)

Gallic Acid Induces S and G2 Phase Arrest and Apoptosis in Human Ovarian Cancer Cells In Vitro
por: He, Zhiping, et al.
Publicado: (2021)

Inhibition of cell migration by ouabain in the A549 human lung cancer cell line
por: LIU, NING, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_girp9hietohtlih5iujqglqa6l