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Inhibition of the Na(+)/K(+)-ATPase by cardiac glycosides suppresses expression of the IDO1 immune checkpoint in cancer cells by reducing STAT1 activation

Despite extensive basic and clinical research on immune checkpoint regulatory pathways, little is known about the effects of the ionic tumor microenvironment on immune checkpoint expression and function. Here we describe a mechanistic link between Na(+)/K(+)-ATPase (NKA) inhibition and activity of t...

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Detalles Bibliográficos
Autores principales:	Shandell, Mia A., Capatina, Alina L., Lawrence, Samantha M., Brackenbury, William J., Lagos, Dimitris
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8902613/ https://www.ncbi.nlm.nih.gov/pubmed/35150740 http://dx.doi.org/10.1016/j.jbc.2022.101707

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