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Engineering of tissue inhibitor of metalloproteinases TIMP-1 for fine discrimination between closely related stromelysins MMP-3 and MMP-10

Matrix metalloproteinases (MMPs) have long been known as key drivers in the development and progression of diseases, including cancer and neurodegenerative, cardiovascular, and many other inflammatory and degenerative diseases, making them attractive potential drug targets. Engineering selective inh...

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Detalles Bibliográficos
Autores principales:	Raeeszadeh-Sarmazdeh, Maryam, Coban, Mathew, Mahajan, Shivansh, Hockla, Alexandra, Sankaran, Banumathi, Downey, Gregory P., Radisky, Derek C., Radisky, Evette S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8902619/ https://www.ncbi.nlm.nih.gov/pubmed/35101440 http://dx.doi.org/10.1016/j.jbc.2022.101654

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