Branching and converging pathways in fungal natural product biosynthesis

In nature, organic molecules with great structural diversity and complexity are synthesized by utilizing a relatively small number of starting materials. A synthetic strategy adopted by nature is pathway branching, in which a common biosynthetic intermediate is transformed into different end product...

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Detalles Bibliográficos
Autores principales: Wei, Xingxing, Wang, Wei-Guang, Matsuda, Yudai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8902786/
https://www.ncbi.nlm.nih.gov/pubmed/35255990
http://dx.doi.org/10.1186/s40694-022-00135-w
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author Wei, Xingxing
Wang, Wei-Guang
Matsuda, Yudai
author_facet Wei, Xingxing
Wang, Wei-Guang
Matsuda, Yudai
author_sort Wei, Xingxing
collection PubMed
description In nature, organic molecules with great structural diversity and complexity are synthesized by utilizing a relatively small number of starting materials. A synthetic strategy adopted by nature is pathway branching, in which a common biosynthetic intermediate is transformed into different end products. A natural product can also be synthesized by the fusion of two or more precursors generated from separate metabolic pathways. This review article summarizes several representative branching and converging pathways in fungal natural product biosynthesis to illuminate how fungi are capable of synthesizing a diverse array of natural products.
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spelling pubmed-89027862022-03-18 Branching and converging pathways in fungal natural product biosynthesis Wei, Xingxing Wang, Wei-Guang Matsuda, Yudai Fungal Biol Biotechnol Review In nature, organic molecules with great structural diversity and complexity are synthesized by utilizing a relatively small number of starting materials. A synthetic strategy adopted by nature is pathway branching, in which a common biosynthetic intermediate is transformed into different end products. A natural product can also be synthesized by the fusion of two or more precursors generated from separate metabolic pathways. This review article summarizes several representative branching and converging pathways in fungal natural product biosynthesis to illuminate how fungi are capable of synthesizing a diverse array of natural products. BioMed Central 2022-03-07 /pmc/articles/PMC8902786/ /pubmed/35255990 http://dx.doi.org/10.1186/s40694-022-00135-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Wei, Xingxing
Wang, Wei-Guang
Matsuda, Yudai
Branching and converging pathways in fungal natural product biosynthesis
title Branching and converging pathways in fungal natural product biosynthesis
title_full Branching and converging pathways in fungal natural product biosynthesis
title_fullStr Branching and converging pathways in fungal natural product biosynthesis
title_full_unstemmed Branching and converging pathways in fungal natural product biosynthesis
title_short Branching and converging pathways in fungal natural product biosynthesis
title_sort branching and converging pathways in fungal natural product biosynthesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8902786/
https://www.ncbi.nlm.nih.gov/pubmed/35255990
http://dx.doi.org/10.1186/s40694-022-00135-w
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