An organoid model of colorectal circulating tumor cells with stem cell features, hybrid EMT state and distinctive therapy response profile

BACKGROUND: Circulating tumor cells (CTCs) are responsible for the metastatic dissemination of colorectal cancer (CRC) to the liver, lungs and lymph nodes. CTCs rarity and heterogeneity strongly limit the elucidation of their biological features, as well as preclinical drug sensitivity studies aimed...

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Detalles Bibliográficos
Autores principales: De Angelis, Maria Laura, Francescangeli, Federica, Nicolazzo, Chiara, Signore, Michele, Giuliani, Alessandro, Colace, Lidia, Boe, Alessandra, Magri, Valentina, Baiocchi, Marta, Ciardi, Antonio, Scarola, Francesco, Spada, Massimo, La Torre, Filippo, Gazzaniga, Paola, Biffoni, Mauro, De Maria, Ruggero, Zeuner, Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8903172/
https://www.ncbi.nlm.nih.gov/pubmed/35260172
http://dx.doi.org/10.1186/s13046-022-02263-y

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