The RNA helicase DHX16 recognizes specific viral RNA to trigger RIG-I-dependent innate antiviral immunity

Type I interferons (IFN-I) are essential to establish antiviral innate immunity. Unanchored (or free) polyubiquitin (poly-Ub) has been shown to regulate IFN-I responses. However, few unanchored poly-Ub interactors are known. To identify factors regulated by unanchored poly-Ub in a physiological sett...

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Detalles Bibliográficos
Autores principales: Hage, Adam, Bharaj, Preeti, van Tol, Sarah, Giraldo, Maria I., Gonzalez-Orozco, Maria, Valerdi, Karl M., Warren, Abbey N., Aguilera-Aguirre, Leopoldo, Xie, Xuping, Widen, Steven G., Moulton, Hong M., Lee, Benhur, Johnson, Jeffrey R., Krogan, Nevan J., García-Sastre, Adolfo, Shi, Pei-Yong, Freiberg, Alexander N., Rajsbaum, Ricardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8903195/
https://www.ncbi.nlm.nih.gov/pubmed/35263596
http://dx.doi.org/10.1016/j.celrep.2022.110434

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