Increased replication stress and R-loop accumulation in EGFRvIII-expressing glioblastoma present new therapeutic opportunities

BACKGROUND: The oncogene epidermal growth factor receptor variant III (EGFRvIII) is expressed in approximately one-third of all glioblastomas (GBMs). So far it is not clear if EGFRvIII expression induces replication stress in GBM cells, which might serve as a therapeutical target. METHODS: Isogeneti...

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Detalles Bibliográficos
Autores principales: Struve, Nina, Hoffer, Konstantin, Weik, Anna-Sophie, Riepen, Britta, Krug, Leonie, Cetin, Meryem H, Burmester, Jasmin, Ott, Leonie, Liebing, Jana, Gatzemeier, Fruzsina, Müller-Goebel, Justus, Gerbach, Mirja, Bußmann, Lara, Parplys, Ann Christin, Unger, Kristian, Mansour, Wael Y, Schüller, Ulrich, Rieckmann, Thorsten, Petersen, Cordula, Rothkamm, Kai, Short, Susan C, Kriegs, Malte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Basic and Translational Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8903237/
https://www.ncbi.nlm.nih.gov/pubmed/35274102
http://dx.doi.org/10.1093/noajnl/vdab180

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