Hospitalization and Mortality Risk for COVID-19 Cases With SARS-CoV-2 AY.4.2 (VUI-21OCT-01) Compared to Non-AY.4.2 Delta Variant Sublineages( )

To investigate if the AY.4.2 sublineage of the SARS-CoV-2 delta variant is associated with hospitalization and mortality risks that differ from non-AY.4.2 delta risks, we performed a retrospective cohort study of sequencing-confirmed COVID-19 cases in England based on linkage of routine health care...

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Detalles Bibliográficos
Autores principales: Nyberg, Tommy, Harman, Katie, Zaidi, Asad, Seaman, Shaun R, Andrews, Nick, Nash, Sophie G, Charlett, Andre, Lopez Bernal, Jamie, Myers, Richard, Groves, Natalie, Gallagher, Eileen, Gharbia, Saheer, Chand, Meera, Thelwall, Simon, De Angelis, Daniela, Dabrera, Gavin, Presanis, Anne M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8903446/
https://www.ncbi.nlm.nih.gov/pubmed/35184201
http://dx.doi.org/10.1093/infdis/jiac063
Descripción
Sumario:To investigate if the AY.4.2 sublineage of the SARS-CoV-2 delta variant is associated with hospitalization and mortality risks that differ from non-AY.4.2 delta risks, we performed a retrospective cohort study of sequencing-confirmed COVID-19 cases in England based on linkage of routine health care datasets. Using stratified Cox regression, we estimated adjusted hazard ratios (aHR) of hospital admission (aHR = 0.85; 95% confidence interval [CI], .77–.94), hospital admission or emergency care attendance (aHR = 0.87; 95% CI, .81–.94), and COVID-19 mortality (aHR = 0.85; 95% CI, .71–1.03). The results indicate that the risks of hospitalization and mortality are similar or lower for AY.4.2 compared to cases with other delta sublineages.

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