Pediatric tizanidine toxicity reversed with naloxone: a case report

BACKGROUND: Tizanidine, an α-2 adrenoceptor agonist, is widely prescribed for the management of spasticity in adults. Case reports on pediatric tizanidine overdose are limited. Here, we report a case of pediatric tizanidine toxicity that was reversed with naloxone. CASE PRESENTATION: A 3-year-old ma...

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Autores principales: Bader, Doaa, Adam, Ahmed, Shaban, Mohamed, Alyahya, Bader
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8903539/
https://www.ncbi.nlm.nih.gov/pubmed/34906071
http://dx.doi.org/10.1186/s12245-021-00397-y
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author Bader, Doaa
Adam, Ahmed
Shaban, Mohamed
Alyahya, Bader
author_facet Bader, Doaa
Adam, Ahmed
Shaban, Mohamed
Alyahya, Bader
author_sort Bader, Doaa
collection PubMed
description BACKGROUND: Tizanidine, an α-2 adrenoceptor agonist, is widely prescribed for the management of spasticity in adults. Case reports on pediatric tizanidine overdose are limited. Here, we report a case of pediatric tizanidine toxicity that was reversed with naloxone. CASE PRESENTATION: A 3-year-old male presented to the emergency department with lethargy, bradycardia, and bradypnea after accidental ingestion of multiple tizanidine tablets. Improvements in the level of consciousness and respiratory and heart rates were observed after two intravenous administrations of naloxone at a dose of 0.05 and 0.1 mg/kg, respectively. CONCLUSIONS: This case report provides further evidence regarding the use of naloxone as a viable antidote for centrally acting α-2 receptor agonists and presents additional epidemiologic data on childhood tizanidine poisoning.
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spelling pubmed-89035392022-03-18 Pediatric tizanidine toxicity reversed with naloxone: a case report Bader, Doaa Adam, Ahmed Shaban, Mohamed Alyahya, Bader Int J Emerg Med Case Report BACKGROUND: Tizanidine, an α-2 adrenoceptor agonist, is widely prescribed for the management of spasticity in adults. Case reports on pediatric tizanidine overdose are limited. Here, we report a case of pediatric tizanidine toxicity that was reversed with naloxone. CASE PRESENTATION: A 3-year-old male presented to the emergency department with lethargy, bradycardia, and bradypnea after accidental ingestion of multiple tizanidine tablets. Improvements in the level of consciousness and respiratory and heart rates were observed after two intravenous administrations of naloxone at a dose of 0.05 and 0.1 mg/kg, respectively. CONCLUSIONS: This case report provides further evidence regarding the use of naloxone as a viable antidote for centrally acting α-2 receptor agonists and presents additional epidemiologic data on childhood tizanidine poisoning. Springer Berlin Heidelberg 2021-12-14 /pmc/articles/PMC8903539/ /pubmed/34906071 http://dx.doi.org/10.1186/s12245-021-00397-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Bader, Doaa
Adam, Ahmed
Shaban, Mohamed
Alyahya, Bader
Pediatric tizanidine toxicity reversed with naloxone: a case report
title Pediatric tizanidine toxicity reversed with naloxone: a case report
title_full Pediatric tizanidine toxicity reversed with naloxone: a case report
title_fullStr Pediatric tizanidine toxicity reversed with naloxone: a case report
title_full_unstemmed Pediatric tizanidine toxicity reversed with naloxone: a case report
title_short Pediatric tizanidine toxicity reversed with naloxone: a case report
title_sort pediatric tizanidine toxicity reversed with naloxone: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8903539/
https://www.ncbi.nlm.nih.gov/pubmed/34906071
http://dx.doi.org/10.1186/s12245-021-00397-y
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AT shabanmohamed pediatrictizanidinetoxicityreversedwithnaloxoneacasereport
AT alyahyabader pediatrictizanidinetoxicityreversedwithnaloxoneacasereport

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