Peptidylarginine deiminase 2 promotes T helper 17-like T cell activation and activated T cell-autonomous death (ACAD) through an endoplasmic reticulum stress and autophagy coupling mechanism

Peptididylarginine deiminase type 2 (PADI2) catalyzes the conversion of arginine residues to citrulline residues on proteins. We demonstrate that PADI2 induces T cell activation and investigate how PADI2 promotes activated T cell autonomous death (ACAD). In activated Jurkat T cells, overexpression o...

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Detalles Bibliográficos
Autores principales: Yang, Yi-Fang, Wang, Chuang-Ming, Hsiao, I.-Hsin, Liu, Yi-Liang, Lin, Wen-Hao, Lin, Chih-Li, Hung, Hui-Chih, Liu, Guang-Yaw
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8903576/
https://www.ncbi.nlm.nih.gov/pubmed/35236296
http://dx.doi.org/10.1186/s11658-022-00312-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8903576/
https://www.ncbi.nlm.nih.gov/pubmed/35236296
http://dx.doi.org/10.1186/s11658-022-00312-0

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