Cargando…
Peptidylarginine deiminase 2 promotes T helper 17-like T cell activation and activated T cell-autonomous death (ACAD) through an endoplasmic reticulum stress and autophagy coupling mechanism
Peptididylarginine deiminase type 2 (PADI2) catalyzes the conversion of arginine residues to citrulline residues on proteins. We demonstrate that PADI2 induces T cell activation and investigate how PADI2 promotes activated T cell autonomous death (ACAD). In activated Jurkat T cells, overexpression o...
Autores principales: | Yang, Yi-Fang, Wang, Chuang-Ming, Hsiao, I.-Hsin, Liu, Yi-Liang, Lin, Wen-Hao, Lin, Chih-Li, Hung, Hui-Chih, Liu, Guang-Yaw |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8903576/ https://www.ncbi.nlm.nih.gov/pubmed/35236296 http://dx.doi.org/10.1186/s11658-022-00312-0 |
Ejemplares similares
-
Vimentin Is Involved in Peptidylarginine Deiminase 2-Induced Apoptosis of Activated Jurkat Cells
por: Hsu, Pei-Chen, et al.
Publicado: (2014) -
Functional Role of Dimerization of Human Peptidylarginine Deiminase 4 (PAD4)
por: Liu, Yi-Liang, et al.
Publicado: (2011) -
Molecular Interplay between the Dimer Interface and the Substrate-Binding Site of Human Peptidylarginine Deiminase 4
por: Lee, Chien-Yun, et al.
Publicado: (2017) -
Probing the Roles of Calcium-Binding Sites during the Folding of Human Peptidylarginine Deiminase 4
por: Liu, Yi-Liang, et al.
Publicado: (2017) -
Anti-peptidylarginine deiminase-4 antibodies at mucosal sites can activate peptidylarginine deiminase-4 enzyme activity in rheumatoid arthritis
por: Demoruelle, M. Kristen, et al.
Publicado: (2021)