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Potential anticancer properties and mechanisms of thymoquinone in osteosarcoma and bone metastasis

Despite great advances, therapeutic approaches of osteosarcoma, the most prevalent class of preliminary pediatric bone tumors, as well as bone-related malignancies, continue to demonstrate insufficient adequacy. In recent years, a growing trend toward applying natural bioactive compounds, particular...

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Autores principales: Homayoonfal, Mina, Asemi, Zatollah, Yousefi, Bahman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8903697/
https://www.ncbi.nlm.nih.gov/pubmed/35236304
http://dx.doi.org/10.1186/s11658-022-00320-0
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author Homayoonfal, Mina
Asemi, Zatollah
Yousefi, Bahman
author_facet Homayoonfal, Mina
Asemi, Zatollah
Yousefi, Bahman
author_sort Homayoonfal, Mina
collection PubMed
description Despite great advances, therapeutic approaches of osteosarcoma, the most prevalent class of preliminary pediatric bone tumors, as well as bone-related malignancies, continue to demonstrate insufficient adequacy. In recent years, a growing trend toward applying natural bioactive compounds, particularly phytochemicals, as novel agents for cancer treatment has been observed. Bioactive phytochemicals exert their anticancer features through two main ways: they induce cytotoxic effects against cancerous cells without having any detrimental impact on normal cell macromolecules such as DNA and enzymes, while at the same time combating the oncogenic signaling axis activated in tumor cells. Thymoquinone (TQ), the most abundant bioactive compound of Nigella sativa, has received considerable attention in cancer treatment owing to its distinctive properties, including apoptosis induction, cell cycle arrest, angiogenesis and metastasis inhibition, and reactive oxygen species (ROS) generation, along with inducing immune system responses and reducing side effects of traditional chemotherapeutic drugs. The present review is focused on the characteristics and mechanisms by which TQ exerts its cytotoxic effects on bone malignancies.
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spelling pubmed-89036972022-03-18 Potential anticancer properties and mechanisms of thymoquinone in osteosarcoma and bone metastasis Homayoonfal, Mina Asemi, Zatollah Yousefi, Bahman Cell Mol Biol Lett Review Despite great advances, therapeutic approaches of osteosarcoma, the most prevalent class of preliminary pediatric bone tumors, as well as bone-related malignancies, continue to demonstrate insufficient adequacy. In recent years, a growing trend toward applying natural bioactive compounds, particularly phytochemicals, as novel agents for cancer treatment has been observed. Bioactive phytochemicals exert their anticancer features through two main ways: they induce cytotoxic effects against cancerous cells without having any detrimental impact on normal cell macromolecules such as DNA and enzymes, while at the same time combating the oncogenic signaling axis activated in tumor cells. Thymoquinone (TQ), the most abundant bioactive compound of Nigella sativa, has received considerable attention in cancer treatment owing to its distinctive properties, including apoptosis induction, cell cycle arrest, angiogenesis and metastasis inhibition, and reactive oxygen species (ROS) generation, along with inducing immune system responses and reducing side effects of traditional chemotherapeutic drugs. The present review is focused on the characteristics and mechanisms by which TQ exerts its cytotoxic effects on bone malignancies. BioMed Central 2022-03-02 /pmc/articles/PMC8903697/ /pubmed/35236304 http://dx.doi.org/10.1186/s11658-022-00320-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Homayoonfal, Mina
Asemi, Zatollah
Yousefi, Bahman
Potential anticancer properties and mechanisms of thymoquinone in osteosarcoma and bone metastasis
title Potential anticancer properties and mechanisms of thymoquinone in osteosarcoma and bone metastasis
title_full Potential anticancer properties and mechanisms of thymoquinone in osteosarcoma and bone metastasis
title_fullStr Potential anticancer properties and mechanisms of thymoquinone in osteosarcoma and bone metastasis
title_full_unstemmed Potential anticancer properties and mechanisms of thymoquinone in osteosarcoma and bone metastasis
title_short Potential anticancer properties and mechanisms of thymoquinone in osteosarcoma and bone metastasis
title_sort potential anticancer properties and mechanisms of thymoquinone in osteosarcoma and bone metastasis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8903697/
https://www.ncbi.nlm.nih.gov/pubmed/35236304
http://dx.doi.org/10.1186/s11658-022-00320-0
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