IFN-γ activates the tumor cell-intrinsic STING pathway through the induction of DNA damage and cytosolic dsDNA formation

Stimulator of interferon genes (STING) pathway activation predicts the effectiveness of targeting the PD-1/PD-L1 axis in lung cancer. Active IFN-γ signaling is a common feature in tumors that respond to PD-1/PD-L1 blockade. The connection between IFN-γ and STING signaling in cancer cells has not bee...

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Detalles Bibliográficos
Autores principales: Xiong, Hui, Xi, Yu, Yuan, Zhiwei, Wang, Boyu, Hu, Shaojie, Fang, Can, Cai, Yixin, Fu, Xiangning, Li, Lequn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8903773/
https://www.ncbi.nlm.nih.gov/pubmed/35273829
http://dx.doi.org/10.1080/2162402X.2022.2044103

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