Low-level SARS-CoV-2 viremia coincident with COVID placentitis and stillbirth

SARS-CoV-2 infection in pregnancy and COVID placentitis are associated with an increased risk of stillbirth. We sought to investigate the presence of maternal viremia in people with SARS-CoV-2 infection during pregnancy who had histologic placentitis versus those without placentitis. SARS-CoV-2 qRT-...

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Detalles Bibliográficos
Autores principales: Mithal, Leena B., Otero, Sebastian, Simons, Lacy M., Hultquist, Judd F., Miller, Emily S., Ozer, Egon A., Shanes, Elisheva D., Goldstein, Jeffery A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904001/
https://www.ncbi.nlm.nih.gov/pubmed/35290925
http://dx.doi.org/10.1016/j.placenta.2022.03.003
Descripción
Sumario:SARS-CoV-2 infection in pregnancy and COVID placentitis are associated with an increased risk of stillbirth. We sought to investigate the presence of maternal viremia in people with SARS-CoV-2 infection during pregnancy who had histologic placentitis versus those without placentitis. SARS-CoV-2 qRT-PCR was performed on plasma from 6 patients with COVID placentitis and 12 matched controls without placentitis. SARS-CoV-2 infection occurred between 4/2020–1/2021; the latency between SARS-CoV-2 diagnosis and delivery was 0–76 days. Two placentitis cases demonstrated viremia (1 stillbirth and 1 well infant), while 12/12 controls were negative. Future research may consider viremia as a possible marker of COVID placentitis.

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