Low-level SARS-CoV-2 viremia coincident with COVID placentitis and stillbirth

SARS-CoV-2 infection in pregnancy and COVID placentitis are associated with an increased risk of stillbirth. We sought to investigate the presence of maternal viremia in people with SARS-CoV-2 infection during pregnancy who had histologic placentitis versus those without placentitis. SARS-CoV-2 qRT-...

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Autores principales: Mithal, Leena B., Otero, Sebastian, Simons, Lacy M., Hultquist, Judd F., Miller, Emily S., Ozer, Egon A., Shanes, Elisheva D., Goldstein, Jeffery A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904001/
https://www.ncbi.nlm.nih.gov/pubmed/35290925
http://dx.doi.org/10.1016/j.placenta.2022.03.003
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author Mithal, Leena B.
Otero, Sebastian
Simons, Lacy M.
Hultquist, Judd F.
Miller, Emily S.
Ozer, Egon A.
Shanes, Elisheva D.
Goldstein, Jeffery A.
author_facet Mithal, Leena B.
Otero, Sebastian
Simons, Lacy M.
Hultquist, Judd F.
Miller, Emily S.
Ozer, Egon A.
Shanes, Elisheva D.
Goldstein, Jeffery A.
author_sort Mithal, Leena B.
collection PubMed
description SARS-CoV-2 infection in pregnancy and COVID placentitis are associated with an increased risk of stillbirth. We sought to investigate the presence of maternal viremia in people with SARS-CoV-2 infection during pregnancy who had histologic placentitis versus those without placentitis. SARS-CoV-2 qRT-PCR was performed on plasma from 6 patients with COVID placentitis and 12 matched controls without placentitis. SARS-CoV-2 infection occurred between 4/2020–1/2021; the latency between SARS-CoV-2 diagnosis and delivery was 0–76 days. Two placentitis cases demonstrated viremia (1 stillbirth and 1 well infant), while 12/12 controls were negative. Future research may consider viremia as a possible marker of COVID placentitis.
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spelling pubmed-89040012022-03-09 Low-level SARS-CoV-2 viremia coincident with COVID placentitis and stillbirth Mithal, Leena B. Otero, Sebastian Simons, Lacy M. Hultquist, Judd F. Miller, Emily S. Ozer, Egon A. Shanes, Elisheva D. Goldstein, Jeffery A. Placenta Article SARS-CoV-2 infection in pregnancy and COVID placentitis are associated with an increased risk of stillbirth. We sought to investigate the presence of maternal viremia in people with SARS-CoV-2 infection during pregnancy who had histologic placentitis versus those without placentitis. SARS-CoV-2 qRT-PCR was performed on plasma from 6 patients with COVID placentitis and 12 matched controls without placentitis. SARS-CoV-2 infection occurred between 4/2020–1/2021; the latency between SARS-CoV-2 diagnosis and delivery was 0–76 days. Two placentitis cases demonstrated viremia (1 stillbirth and 1 well infant), while 12/12 controls were negative. Future research may consider viremia as a possible marker of COVID placentitis. Elsevier Ltd. 2022-04 2022-03-09 /pmc/articles/PMC8904001/ /pubmed/35290925 http://dx.doi.org/10.1016/j.placenta.2022.03.003 Text en © 2022 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Mithal, Leena B.
Otero, Sebastian
Simons, Lacy M.
Hultquist, Judd F.
Miller, Emily S.
Ozer, Egon A.
Shanes, Elisheva D.
Goldstein, Jeffery A.
Low-level SARS-CoV-2 viremia coincident with COVID placentitis and stillbirth
title Low-level SARS-CoV-2 viremia coincident with COVID placentitis and stillbirth
title_full Low-level SARS-CoV-2 viremia coincident with COVID placentitis and stillbirth
title_fullStr Low-level SARS-CoV-2 viremia coincident with COVID placentitis and stillbirth
title_full_unstemmed Low-level SARS-CoV-2 viremia coincident with COVID placentitis and stillbirth
title_short Low-level SARS-CoV-2 viremia coincident with COVID placentitis and stillbirth
title_sort low-level sars-cov-2 viremia coincident with covid placentitis and stillbirth
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904001/
https://www.ncbi.nlm.nih.gov/pubmed/35290925
http://dx.doi.org/10.1016/j.placenta.2022.03.003
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