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Comparison between Ibuprofen and Acetaminophen in the Treatment of Infectious Fever in Children: A Meta-Analysis

BACKGROUND: To evaluate ibuprofen and acetaminophen in the treatment of infectious fever in children. METHODS: We searched randomized controlled trials and retrospective cohort studies comparing ibuprofen and acetaminophen in the treatment of infectious fever among children. Data were extracted from...

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Autores principales: Yin, Fengrui, Liu, Yu, Guo, Hongxian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904092/
https://www.ncbi.nlm.nih.gov/pubmed/35273783
http://dx.doi.org/10.1155/2022/1794258
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author Yin, Fengrui
Liu, Yu
Guo, Hongxian
author_facet Yin, Fengrui
Liu, Yu
Guo, Hongxian
author_sort Yin, Fengrui
collection PubMed
description BACKGROUND: To evaluate ibuprofen and acetaminophen in the treatment of infectious fever in children. METHODS: We searched randomized controlled trials and retrospective cohort studies comparing ibuprofen and acetaminophen in the treatment of infectious fever among children. Data were extracted from eligible studies. We sought to evaluate temperature after taking drugs in 1, 2, and 4 hours, respectively, and analyzed the adverse events. Results were expressed as mean difference(MD) and risk ratio (RR) with 95% confidence intervals. RESULTS: Ten studies were included in this study with a total of 1773 patients. The results showed that acetaminophen had higher temperature than ibuprofen after 1 hour (The overall mean difference was −0.29 with 95% CI (−0.49, −0.09). The P value of the overall effect was = 0.004, I(2) = 91%), 2 hours (MD = −0.46, 95% CI (−0.67, −0.25), P < 0.00001, I(2) = 95%), and 4 hours (MD = -0.57, 95% CI (−0.82, −0.33), P < 0.00001, I(2) = 97%). There is no difference between two drugs in the adverse events (RR = 0.8, 95% CI (0.52, 1.24), P = 0.32, I(2) = 0%). The sensitivity analysis and funnel plot showed that our study was robust and had low publication bias. CONCLUSION: Our study suggested that ibuprofen is more effective than acetaminophen in children with infectious fever.
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spelling pubmed-89040922022-03-09 Comparison between Ibuprofen and Acetaminophen in the Treatment of Infectious Fever in Children: A Meta-Analysis Yin, Fengrui Liu, Yu Guo, Hongxian J Healthc Eng Research Article BACKGROUND: To evaluate ibuprofen and acetaminophen in the treatment of infectious fever in children. METHODS: We searched randomized controlled trials and retrospective cohort studies comparing ibuprofen and acetaminophen in the treatment of infectious fever among children. Data were extracted from eligible studies. We sought to evaluate temperature after taking drugs in 1, 2, and 4 hours, respectively, and analyzed the adverse events. Results were expressed as mean difference(MD) and risk ratio (RR) with 95% confidence intervals. RESULTS: Ten studies were included in this study with a total of 1773 patients. The results showed that acetaminophen had higher temperature than ibuprofen after 1 hour (The overall mean difference was −0.29 with 95% CI (−0.49, −0.09). The P value of the overall effect was = 0.004, I(2) = 91%), 2 hours (MD = −0.46, 95% CI (−0.67, −0.25), P < 0.00001, I(2) = 95%), and 4 hours (MD = -0.57, 95% CI (−0.82, −0.33), P < 0.00001, I(2) = 97%). There is no difference between two drugs in the adverse events (RR = 0.8, 95% CI (0.52, 1.24), P = 0.32, I(2) = 0%). The sensitivity analysis and funnel plot showed that our study was robust and had low publication bias. CONCLUSION: Our study suggested that ibuprofen is more effective than acetaminophen in children with infectious fever. Hindawi 2022-03-01 /pmc/articles/PMC8904092/ /pubmed/35273783 http://dx.doi.org/10.1155/2022/1794258 Text en Copyright © 2022 Fengrui Yin et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yin, Fengrui
Liu, Yu
Guo, Hongxian
Comparison between Ibuprofen and Acetaminophen in the Treatment of Infectious Fever in Children: A Meta-Analysis
title Comparison between Ibuprofen and Acetaminophen in the Treatment of Infectious Fever in Children: A Meta-Analysis
title_full Comparison between Ibuprofen and Acetaminophen in the Treatment of Infectious Fever in Children: A Meta-Analysis
title_fullStr Comparison between Ibuprofen and Acetaminophen in the Treatment of Infectious Fever in Children: A Meta-Analysis
title_full_unstemmed Comparison between Ibuprofen and Acetaminophen in the Treatment of Infectious Fever in Children: A Meta-Analysis
title_short Comparison between Ibuprofen and Acetaminophen in the Treatment of Infectious Fever in Children: A Meta-Analysis
title_sort comparison between ibuprofen and acetaminophen in the treatment of infectious fever in children: a meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904092/
https://www.ncbi.nlm.nih.gov/pubmed/35273783
http://dx.doi.org/10.1155/2022/1794258
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