Acetyl-CoA synthetases ACSS1 and ACSS2 are 4-hydroxytamoxifen responsive factors that promote survival in tamoxifen treated and estrogen deprived cells

Acetyl-CoA synthetases ACSS1 and ACSS2 promote conversion of acetate to acetyl-CoA for use in lipid synthesis, protein acetylation, and energy production. These enzymes are elevated in some cancers and important for cell survival under hypoxia and nutrient stress. 4-hydroxytamoxifen (4-OHT) can indu...

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Detalles Bibliográficos
Autores principales: Calhoun, Sarah, Duan, Lei, Maki, Carl G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904238/
https://www.ncbi.nlm.nih.gov/pubmed/35263700
http://dx.doi.org/10.1016/j.tranon.2022.101386

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904238/
https://www.ncbi.nlm.nih.gov/pubmed/35263700
http://dx.doi.org/10.1016/j.tranon.2022.101386

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