Oligodendrocyte precursor cells sculpt the visual system by regulating axonal remodeling

Many oligodendrocyte precursor cells (OPCs) do not differentiate to form myelin, suggesting additional roles of this cell population. The zebrafish optic tectum contains OPCs in regions devoid of myelin. Elimination of these OPCs impaired precise control of retinal ganglion cell axon arbor size duri...

Descripción completa

Detalles Bibliográficos
Autores principales: Xiao, Yan, Petrucco, Luigi, Hoodless, Laura J., Portugues, Ruben, Czopka, Tim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904260/
https://www.ncbi.nlm.nih.gov/pubmed/35241802
http://dx.doi.org/10.1038/s41593-022-01023-7
_version_ 1784664916692566016
author Xiao, Yan
Petrucco, Luigi
Hoodless, Laura J.
Portugues, Ruben
Czopka, Tim
author_facet Xiao, Yan
Petrucco, Luigi
Hoodless, Laura J.
Portugues, Ruben
Czopka, Tim
author_sort Xiao, Yan
collection PubMed
description Many oligodendrocyte precursor cells (OPCs) do not differentiate to form myelin, suggesting additional roles of this cell population. The zebrafish optic tectum contains OPCs in regions devoid of myelin. Elimination of these OPCs impaired precise control of retinal ganglion cell axon arbor size during formation and maturation of retinotectal connectivity and degraded functional processing of visual stimuli. Therefore, OPCs fine-tune neural circuits independently of their canonical role to make myelin.
format Online
Article
Text
id pubmed-8904260
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Nature Publishing Group US
record_format MEDLINE/PubMed
spelling pubmed-89042602022-03-23 Oligodendrocyte precursor cells sculpt the visual system by regulating axonal remodeling Xiao, Yan Petrucco, Luigi Hoodless, Laura J. Portugues, Ruben Czopka, Tim Nat Neurosci Brief Communication Many oligodendrocyte precursor cells (OPCs) do not differentiate to form myelin, suggesting additional roles of this cell population. The zebrafish optic tectum contains OPCs in regions devoid of myelin. Elimination of these OPCs impaired precise control of retinal ganglion cell axon arbor size during formation and maturation of retinotectal connectivity and degraded functional processing of visual stimuli. Therefore, OPCs fine-tune neural circuits independently of their canonical role to make myelin. Nature Publishing Group US 2022-03-03 2022 /pmc/articles/PMC8904260/ /pubmed/35241802 http://dx.doi.org/10.1038/s41593-022-01023-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Communication
Xiao, Yan
Petrucco, Luigi
Hoodless, Laura J.
Portugues, Ruben
Czopka, Tim
Oligodendrocyte precursor cells sculpt the visual system by regulating axonal remodeling
title Oligodendrocyte precursor cells sculpt the visual system by regulating axonal remodeling
title_full Oligodendrocyte precursor cells sculpt the visual system by regulating axonal remodeling
title_fullStr Oligodendrocyte precursor cells sculpt the visual system by regulating axonal remodeling
title_full_unstemmed Oligodendrocyte precursor cells sculpt the visual system by regulating axonal remodeling
title_short Oligodendrocyte precursor cells sculpt the visual system by regulating axonal remodeling
title_sort oligodendrocyte precursor cells sculpt the visual system by regulating axonal remodeling
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904260/
https://www.ncbi.nlm.nih.gov/pubmed/35241802
http://dx.doi.org/10.1038/s41593-022-01023-7
work_keys_str_mv AT xiaoyan oligodendrocyteprecursorcellssculptthevisualsystembyregulatingaxonalremodeling
AT petruccoluigi oligodendrocyteprecursorcellssculptthevisualsystembyregulatingaxonalremodeling
AT hoodlesslauraj oligodendrocyteprecursorcellssculptthevisualsystembyregulatingaxonalremodeling
AT portuguesruben oligodendrocyteprecursorcellssculptthevisualsystembyregulatingaxonalremodeling
AT czopkatim oligodendrocyteprecursorcellssculptthevisualsystembyregulatingaxonalremodeling

Ejemplares similares