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Independent Drug Action in Combination Therapy: Implications for Precision Oncology

Combination therapies are superior to monotherapy for many cancers. This advantage was historically ascribed to the ability of combinations to address tumor heterogeneity, but synergistic interaction is now a common explanation as well as a design criterion for new combinations. We review evidence t...

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Detalles Bibliográficos
Autores principales: Plana, Deborah, Palmer, Adam C., Sorger, Peter K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904281/
https://www.ncbi.nlm.nih.gov/pubmed/34983746
http://dx.doi.org/10.1158/2159-8290.CD-21-0212