Repertoire analyses reveal T cell receptor sequence features that influence T cell fate

T cells acquire a regulatory phenotype when their T cell receptors (TCRs) experience an intermediate-to-high affinity interaction with a self-peptide presented via the major histocompatibility complex (MHC). Using TCRβ sequences from flow-sorted human cells, we identified TCR features that promote r...

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Detalles Bibliográficos
Autores principales: Lagattuta, Kaitlyn A., Kang, Joyce B., Nathan, Aparna, Pauken, Kristen E., Jonsson, Anna Helena, Rao, Deepak A., Sharpe, Arlene H., Ishigaki, Kazuyoshi, Raychaudhuri, Soumya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904286/
https://www.ncbi.nlm.nih.gov/pubmed/35177831
http://dx.doi.org/10.1038/s41590-022-01129-x

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