PTP1B Is an Intracellular Checkpoint that Limits T-cell and CAR T-cell Antitumor Immunity

Immunotherapies aimed at alleviating the inhibitory constraints on T cells have revolutionized cancer management. To date, these have focused on the blockade of cell-surface checkpoints such as PD-1. Herein we identify protein tyrosine phosphatase 1B (PTP1B) as an intracellular checkpoint that is up...

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Detalles Bibliográficos
Autores principales: Wiede, Florian, Lu, Kun-Hui, Du, Xin, Zeissig, Mara N., Xu, Rachel, Goh, Pei Kee, Xirouchaki, Chrysovalantou E., Hogarth, Samuel J., Greatorex, Spencer, Sek, Kevin, Daly, Roger J., Beavis, Paul A., Darcy, Phillip K., Tonks, Nicholas K., Tiganis, Tony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904293/
https://www.ncbi.nlm.nih.gov/pubmed/34794959
http://dx.doi.org/10.1158/2159-8290.CD-21-0694

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