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Geographic determinants of colorectal cancer in Louisiana

PURPOSE: Currently, rural residents in the United States (US) experience a greater cancer burden for tobacco-related cancers and cancers that can be prevented by screening. We aim to characterize geographic determinants of colorectal cancer (CRC) incidence in Louisiana due to rural residence and oth...

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Autores principales: Danos, Denise, Leonardi, Claudia, Wu, Xiao-Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904347/
https://www.ncbi.nlm.nih.gov/pubmed/34994869
http://dx.doi.org/10.1007/s10552-021-01546-7
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author Danos, Denise
Leonardi, Claudia
Wu, Xiao-Cheng
author_facet Danos, Denise
Leonardi, Claudia
Wu, Xiao-Cheng
author_sort Danos, Denise
collection PubMed
description PURPOSE: Currently, rural residents in the United States (US) experience a greater cancer burden for tobacco-related cancers and cancers that can be prevented by screening. We aim to characterize geographic determinants of colorectal cancer (CRC) incidence in Louisiana due to rural residence and other known geographic risk factors, area socioeconomic status (SES), and cultural region (Acadian or French-speaking). METHODS: Primary colorectal cancer diagnosed among adults 30 years and older in 2008–2017 were obtained from the Louisiana Tumor Registry. Population and social and economic data were obtained from US Census American Community Survey. Rural areas were defined using US Department of Agriculture 2010 rural–urban commuting area codes. Estimates of relative risk (RR) were obtained from multilevel binomial regression models of incidence. RESULTS: The study population was 16.1% rural, 18.4% low SES, and 17.9% Acadian. Risk of CRC was greater among rural white residents (RR Women: 1.09(1.02–1.16), RR Men: 1.11(1.04–1.18)). Low SES was associated with increased CRC for all demographic groups, with excess risk ranging from 8% in Black men (RR: 1.08(1.01–1.16)) to 16% in white men (RR: 1.16(1.08–1.24)). Increased risk in the Acadian region was greatest for Black men (RR: 1.21(1.10–1.33)) and women (RR: 1.21(1.09–1.33)). Rural–urban disparities in CRC were no longer significant after controlling for SES and Acadian region. CONCLUSION: SES remains a significant determinant of CRC disparities in Louisiana and may contribute to observed rural–urban disparities in the state. While the intersectionality of CRC risk factors is complex, we have confirmed a robust regional disparity for the Acadian region of Louisiana. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10552-021-01546-7.
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spelling pubmed-89043472022-03-15 Geographic determinants of colorectal cancer in Louisiana Danos, Denise Leonardi, Claudia Wu, Xiao-Cheng Cancer Causes Control Original Paper PURPOSE: Currently, rural residents in the United States (US) experience a greater cancer burden for tobacco-related cancers and cancers that can be prevented by screening. We aim to characterize geographic determinants of colorectal cancer (CRC) incidence in Louisiana due to rural residence and other known geographic risk factors, area socioeconomic status (SES), and cultural region (Acadian or French-speaking). METHODS: Primary colorectal cancer diagnosed among adults 30 years and older in 2008–2017 were obtained from the Louisiana Tumor Registry. Population and social and economic data were obtained from US Census American Community Survey. Rural areas were defined using US Department of Agriculture 2010 rural–urban commuting area codes. Estimates of relative risk (RR) were obtained from multilevel binomial regression models of incidence. RESULTS: The study population was 16.1% rural, 18.4% low SES, and 17.9% Acadian. Risk of CRC was greater among rural white residents (RR Women: 1.09(1.02–1.16), RR Men: 1.11(1.04–1.18)). Low SES was associated with increased CRC for all demographic groups, with excess risk ranging from 8% in Black men (RR: 1.08(1.01–1.16)) to 16% in white men (RR: 1.16(1.08–1.24)). Increased risk in the Acadian region was greatest for Black men (RR: 1.21(1.10–1.33)) and women (RR: 1.21(1.09–1.33)). Rural–urban disparities in CRC were no longer significant after controlling for SES and Acadian region. CONCLUSION: SES remains a significant determinant of CRC disparities in Louisiana and may contribute to observed rural–urban disparities in the state. While the intersectionality of CRC risk factors is complex, we have confirmed a robust regional disparity for the Acadian region of Louisiana. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10552-021-01546-7. Springer International Publishing 2022-01-07 2022 /pmc/articles/PMC8904347/ /pubmed/34994869 http://dx.doi.org/10.1007/s10552-021-01546-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Paper
Danos, Denise
Leonardi, Claudia
Wu, Xiao-Cheng
Geographic determinants of colorectal cancer in Louisiana
title Geographic determinants of colorectal cancer in Louisiana
title_full Geographic determinants of colorectal cancer in Louisiana
title_fullStr Geographic determinants of colorectal cancer in Louisiana
title_full_unstemmed Geographic determinants of colorectal cancer in Louisiana
title_short Geographic determinants of colorectal cancer in Louisiana
title_sort geographic determinants of colorectal cancer in louisiana
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904347/
https://www.ncbi.nlm.nih.gov/pubmed/34994869
http://dx.doi.org/10.1007/s10552-021-01546-7
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