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NAD+ depletion enhances reovirus-induced oncolysis in multiple myeloma

Cancer cell energy metabolism plays an important role in dictating the efficacy of oncolysis by oncolytic viruses. To understand the role of multiple myeloma metabolism in reovirus oncolysis, we performed semi-targeted mass spectrometry-based metabolomics on 12 multiple myeloma cell lines and reveal...

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Detalles Bibliográficos
Autores principales:	Kennedy, Barry E., Giacomantonio, Michael, Murphy, J. Patrick, Cutler, Samuel, Sadek, Maryanne, Konda, Prathyusha, Paulo, Joao A., Pathak, Gopal P., Renkens, Saskia H.J., Grieve, Stacy, Pol, Jonathan, Gygi, Steven P., Richardson, Christopher, Gaston, Daniel, Reiman, Anthony, Kroemer, Guido, Elnenaei, Manal O., Gujar, Shashi A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904403/ https://www.ncbi.nlm.nih.gov/pubmed/35284625 http://dx.doi.org/10.1016/j.omto.2022.02.017

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