A systematic approach for evaluating the role of surface-exposed loops in trypsin-like serine proteases applied to the 170 loop in coagulation factor VIIa

Proteases play a major role in many vital physiological processes. Trypsin-like serine proteases (TLPs), in particular, are paramount in proteolytic cascade systems such as blood coagulation and complement activation. The structural topology of TLPs is highly conserved, with the trypsin fold compris...

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Detalles Bibliográficos
Autores principales: Sorensen, Anders B., Greisen, Per Jr., Madsen, Jesper J., Lund, Jacob, Andersen, Gorm, Wulff-Larsen, Pernille G., Pedersen, Anette A., Gandhi, Prafull S., Overgaard, Michael T., Østergaard, Henrik, Olsen, Ole H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904457/
https://www.ncbi.nlm.nih.gov/pubmed/35260627
http://dx.doi.org/10.1038/s41598-022-07620-7

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