PGE2 activates EP4 in subchondral bone osteoclasts to regulate osteoarthritis

Prostaglandin E2 (PGE2), a major cyclooxygenase-2 (COX-2) product, is highly secreted by the osteoblast lineage in the subchondral bone tissue of osteoarthritis (OA) patients. However, NSAIDs, including COX-2 inhibitors, have severe side effects during OA treatment. Therefore, the identification of...

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Detalles Bibliográficos
Autores principales: Jiang, Wenhao, Jin, Yunyun, Zhang, Shiwei, Ding, Yi, Huo, Konglin, Yang, Junjie, Zhao, Lei, Nian, Baoning, Zhong, Tao P., Lu, Weiqiang, Zhang, Hankun, Cao, Xu, Shah, Karan Mehul, Wang, Ning, Liu, Mingyao, Luo, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904489/
https://www.ncbi.nlm.nih.gov/pubmed/35260562
http://dx.doi.org/10.1038/s41413-022-00201-4

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