Inhibition of the ISR abrogates mGluR5-dependent long-term depression and spatial memory deficits in a rat model of Alzheimer’s disease

Soluble amyloid-β-protein (Aβ) oligomers, a major hallmark of AD, trigger the integrated stress response (ISR) via multiple pathologies including neuronal hyperactivation, microvascular hypoxia, and neuroinflammation. Increasing eIF2α phosphorylation, the core event of ISR, facilitates metabotropic...

Descripción completa

Detalles Bibliográficos
Autores principales: Hu, Zhengtao, Yu, Pengpeng, Zhang, Yangyang, Yang, Yin, Zhu, Manyi, Qin, Shuangying, Xu, Ji-Tian, Duan, Dongxiao, Wu, Yong, Wang, Deguo, Rowan, Michael J., Hu, Neng-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904583/
https://www.ncbi.nlm.nih.gov/pubmed/35260557
http://dx.doi.org/10.1038/s41398-022-01862-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904583/
https://www.ncbi.nlm.nih.gov/pubmed/35260557
http://dx.doi.org/10.1038/s41398-022-01862-9

Ejemplares similares