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Evaluation of choroidal melanin-containing tissue in healthy Japanese subjects by polarization-sensitive optical coherence tomography

In this study, the choroidal melanin content in healthy eyes was evaluated with polarization-sensitive optical coherence tomography (PS-OCT). We evaluated 105 healthy eyes of 105 Japanese subjects. The mean thickness of melanin-containing tissue in the choroid (thickness of MeCh) and the choroidal m...

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Autores principales: Miura, Masahiro, Makita, Shuichi, Yasuno, Yoshiaki, Iwasaki, Takuya, Azuma, Shinnosuke, Mino, Toshihiro, Yamaguchi, Tatsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904585/
https://www.ncbi.nlm.nih.gov/pubmed/35260673
http://dx.doi.org/10.1038/s41598-022-07818-9
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author Miura, Masahiro
Makita, Shuichi
Yasuno, Yoshiaki
Iwasaki, Takuya
Azuma, Shinnosuke
Mino, Toshihiro
Yamaguchi, Tatsuo
author_facet Miura, Masahiro
Makita, Shuichi
Yasuno, Yoshiaki
Iwasaki, Takuya
Azuma, Shinnosuke
Mino, Toshihiro
Yamaguchi, Tatsuo
author_sort Miura, Masahiro
collection PubMed
description In this study, the choroidal melanin content in healthy eyes was evaluated with polarization-sensitive optical coherence tomography (PS-OCT). We evaluated 105 healthy eyes of 105 Japanese subjects. The mean thickness of melanin-containing tissue in the choroid (thickness of MeCh) and the choroidal melanin occupancy rate within a 5-mm circular region from the foveal center were calculated using the degree of polarization uniformity obtained by PS-OCT and compared with the choroidal thickness, patient age, and axial length. To evaluate regional variations, the 5-mm circular region was divided into a center area and an outer ring area, and the outer ring area was further divided into four areas (nasal, temporal, superior, and inferior). The mean thickness of MeCh showed a significant positive correlation with the choroidal thickness. The mean choroidal melanin occupancy rate showed a significant positive correlation with age. The mean choroidal melanin occupancy rate of the center area was significantly larger than that of the outer ring area. The mean thickness of MeCh and choroidal melanin occupancy rate of the nasal area were significantly lower than those of other areas. The distribution of melanin-containing tissue in the choroid varies significantly with age and location.
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spelling pubmed-89045852022-03-09 Evaluation of choroidal melanin-containing tissue in healthy Japanese subjects by polarization-sensitive optical coherence tomography Miura, Masahiro Makita, Shuichi Yasuno, Yoshiaki Iwasaki, Takuya Azuma, Shinnosuke Mino, Toshihiro Yamaguchi, Tatsuo Sci Rep Article In this study, the choroidal melanin content in healthy eyes was evaluated with polarization-sensitive optical coherence tomography (PS-OCT). We evaluated 105 healthy eyes of 105 Japanese subjects. The mean thickness of melanin-containing tissue in the choroid (thickness of MeCh) and the choroidal melanin occupancy rate within a 5-mm circular region from the foveal center were calculated using the degree of polarization uniformity obtained by PS-OCT and compared with the choroidal thickness, patient age, and axial length. To evaluate regional variations, the 5-mm circular region was divided into a center area and an outer ring area, and the outer ring area was further divided into four areas (nasal, temporal, superior, and inferior). The mean thickness of MeCh showed a significant positive correlation with the choroidal thickness. The mean choroidal melanin occupancy rate showed a significant positive correlation with age. The mean choroidal melanin occupancy rate of the center area was significantly larger than that of the outer ring area. The mean thickness of MeCh and choroidal melanin occupancy rate of the nasal area were significantly lower than those of other areas. The distribution of melanin-containing tissue in the choroid varies significantly with age and location. Nature Publishing Group UK 2022-03-08 /pmc/articles/PMC8904585/ /pubmed/35260673 http://dx.doi.org/10.1038/s41598-022-07818-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Miura, Masahiro
Makita, Shuichi
Yasuno, Yoshiaki
Iwasaki, Takuya
Azuma, Shinnosuke
Mino, Toshihiro
Yamaguchi, Tatsuo
Evaluation of choroidal melanin-containing tissue in healthy Japanese subjects by polarization-sensitive optical coherence tomography
title Evaluation of choroidal melanin-containing tissue in healthy Japanese subjects by polarization-sensitive optical coherence tomography
title_full Evaluation of choroidal melanin-containing tissue in healthy Japanese subjects by polarization-sensitive optical coherence tomography
title_fullStr Evaluation of choroidal melanin-containing tissue in healthy Japanese subjects by polarization-sensitive optical coherence tomography
title_full_unstemmed Evaluation of choroidal melanin-containing tissue in healthy Japanese subjects by polarization-sensitive optical coherence tomography
title_short Evaluation of choroidal melanin-containing tissue in healthy Japanese subjects by polarization-sensitive optical coherence tomography
title_sort evaluation of choroidal melanin-containing tissue in healthy japanese subjects by polarization-sensitive optical coherence tomography
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904585/
https://www.ncbi.nlm.nih.gov/pubmed/35260673
http://dx.doi.org/10.1038/s41598-022-07818-9
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