S-SCAM inhibits Axin-dependent synaptic function of GSK3β in a sex-dependent manner

S-SCAM/MAGI-2 gene duplication is associated with schizophrenia (SCZ). S-SCAM overexpression in the forebrain induces SCZ-like phenotypes in a transgenic (Tg) mouse model. Interestingly, S-SCAM Tg mice show male-specific impairments in synaptic plasticity and working memory. However, mechanisms unde...

Descripción completa

Detalles Bibliográficos
Autores principales: Kearney, Gillian, Grau, David, Nieves Torres, Damaris, Shin, Seung Min, Lee, Sang H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904762/
https://www.ncbi.nlm.nih.gov/pubmed/35260764
http://dx.doi.org/10.1038/s41598-022-08220-1

Ejemplares similares

Ejemplares similares