Cargando…
Radioactive iodine and female fertility
Radioactive iodine (I(131)) is used after surgery in the treatment of Differentiated Thyroid Carcinoma (DTC). There is no solid evidence about the potential deleterious effect of I(131) on women fertility. The objective of this study is to assess the impact that I(131) may have on fertility in women...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904766/ https://www.ncbi.nlm.nih.gov/pubmed/35260614 http://dx.doi.org/10.1038/s41598-022-07592-8 |
_version_ | 1784665016424726528 |
---|---|
author | Navarro, Pino Rocher, Sandra Miró-Martínez, Pau Oltra-Crespo, Sandra |
author_facet | Navarro, Pino Rocher, Sandra Miró-Martínez, Pau Oltra-Crespo, Sandra |
author_sort | Navarro, Pino |
collection | PubMed |
description | Radioactive iodine (I(131)) is used after surgery in the treatment of Differentiated Thyroid Carcinoma (DTC). There is no solid evidence about the potential deleterious effect of I(131) on women fertility. The objective of this study is to assess the impact that I(131) may have on fertility in women. All women followed by DTC in our department have been analyzed and women younger than 45 years old at the time of diagnosis and initial treatment were included. There were 40 women exposed to I(131) (study group) and 11 women who were only treated with thyroidectomy (control group). Of the women exposed to I(131), 40% went through early menopause, while no cases were reported among their controls. Furthermore, 29.2% of women exposed to I(131) had decreased Antimüllerian Hormone (AMH), compared to the only 11% of unexposed women (not significant). Regarding the fertility impairment "perceived" by patients, in the group of women exposed to iodine, 17.9% described being unable to complete their genesic desire whereas, none was registered in the control group. We conclude that radioactive iodine can affect a woman's fertility and shorten her reproductive life, so this is an aspect that should be taken into consideration. |
format | Online Article Text |
id | pubmed-8904766 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-89047662022-03-10 Radioactive iodine and female fertility Navarro, Pino Rocher, Sandra Miró-Martínez, Pau Oltra-Crespo, Sandra Sci Rep Article Radioactive iodine (I(131)) is used after surgery in the treatment of Differentiated Thyroid Carcinoma (DTC). There is no solid evidence about the potential deleterious effect of I(131) on women fertility. The objective of this study is to assess the impact that I(131) may have on fertility in women. All women followed by DTC in our department have been analyzed and women younger than 45 years old at the time of diagnosis and initial treatment were included. There were 40 women exposed to I(131) (study group) and 11 women who were only treated with thyroidectomy (control group). Of the women exposed to I(131), 40% went through early menopause, while no cases were reported among their controls. Furthermore, 29.2% of women exposed to I(131) had decreased Antimüllerian Hormone (AMH), compared to the only 11% of unexposed women (not significant). Regarding the fertility impairment "perceived" by patients, in the group of women exposed to iodine, 17.9% described being unable to complete their genesic desire whereas, none was registered in the control group. We conclude that radioactive iodine can affect a woman's fertility and shorten her reproductive life, so this is an aspect that should be taken into consideration. Nature Publishing Group UK 2022-03-08 /pmc/articles/PMC8904766/ /pubmed/35260614 http://dx.doi.org/10.1038/s41598-022-07592-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Navarro, Pino Rocher, Sandra Miró-Martínez, Pau Oltra-Crespo, Sandra Radioactive iodine and female fertility |
title | Radioactive iodine and female fertility |
title_full | Radioactive iodine and female fertility |
title_fullStr | Radioactive iodine and female fertility |
title_full_unstemmed | Radioactive iodine and female fertility |
title_short | Radioactive iodine and female fertility |
title_sort | radioactive iodine and female fertility |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904766/ https://www.ncbi.nlm.nih.gov/pubmed/35260614 http://dx.doi.org/10.1038/s41598-022-07592-8 |
work_keys_str_mv | AT navarropino radioactiveiodineandfemalefertility AT rochersandra radioactiveiodineandfemalefertility AT miromartinezpau radioactiveiodineandfemalefertility AT oltracresposandra radioactiveiodineandfemalefertility |