CX-5461 induces radiosensitization through modification of the DNA damage response and not inhibition of RNA polymerase I

Increased ribosome biogenesis is a distinguishing feature of cancer cells, and small molecule inhibitors of ribosome biogenesis are currently in clinical trials as single agent therapy. It has been previously shown that inhibiting ribosome biogenesis through the inhibition of nuclear export of ribos...

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Detalles Bibliográficos
Autores principales: Lehman, Stacey L., Schwartz, Kayla R., Maheshwari, Shrankhla, Camphausen, Kevin, Tofilon, Philip J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904802/
https://www.ncbi.nlm.nih.gov/pubmed/35260696
http://dx.doi.org/10.1038/s41598-022-07928-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904802/
https://www.ncbi.nlm.nih.gov/pubmed/35260696
http://dx.doi.org/10.1038/s41598-022-07928-4

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