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CX-5461 induces radiosensitization through modification of the DNA damage response and not inhibition of RNA polymerase I
Increased ribosome biogenesis is a distinguishing feature of cancer cells, and small molecule inhibitors of ribosome biogenesis are currently in clinical trials as single agent therapy. It has been previously shown that inhibiting ribosome biogenesis through the inhibition of nuclear export of ribos...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904802/ https://www.ncbi.nlm.nih.gov/pubmed/35260696 http://dx.doi.org/10.1038/s41598-022-07928-4 |