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Gut microbiota and the prevalence and incidence of renal stones

The role of the gut microbiome in the development of renal stone diseases has not been well characterized. This study focused on the taxonomic and functional profiles of gut microbiomes according to the prevalence and incidence of nephrolithiasis. Stool samples from 915 Korean adults were collected...

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Autores principales: Kim, Han-Na, Kim, Jae Heon, Chang, Yoosoo, Yang, Dongmin, Joo, Kwan Joong, Cho, Young-Sam, Park, Heung Jae, Kim, Hyung-Lae, Ryu, Seungho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904816/
https://www.ncbi.nlm.nih.gov/pubmed/35260689
http://dx.doi.org/10.1038/s41598-022-07796-y
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author Kim, Han-Na
Kim, Jae Heon
Chang, Yoosoo
Yang, Dongmin
Joo, Kwan Joong
Cho, Young-Sam
Park, Heung Jae
Kim, Hyung-Lae
Ryu, Seungho
author_facet Kim, Han-Na
Kim, Jae Heon
Chang, Yoosoo
Yang, Dongmin
Joo, Kwan Joong
Cho, Young-Sam
Park, Heung Jae
Kim, Hyung-Lae
Ryu, Seungho
author_sort Kim, Han-Na
collection PubMed
description The role of the gut microbiome in the development of renal stone diseases has not been well characterized. This study focused on the taxonomic and functional profiles of gut microbiomes according to the prevalence and incidence of nephrolithiasis. Stool samples from 915 Korean adults were collected at baseline. Participants were followed for a median of 4.0 years. We evaluated the biodiversity of the gut microbiota and taxonomic profiles associated with nephrolithiasis status, using 16S rRNA gene sequencing. Nephrolithiasis status was categorized into three groups: control (no-stone at both baseline and follow-up visits), incidental nephrolithiasis, and prevalent nephrolithiasis. Compared to the control and incidental nephrolithiasis, the prevalent nephrolithiasis showed a reduced evenness in alpha diversity. Nephrolithiasis was associated with a reduced abundance of some key taxa involved in short-chain fatty acid production. Moreover, the abundance of Bifidobacterium, which possess oxalate-degrading ability, was higher in the control. Conversely, there was no significant difference in the bacterial composition between the incidental and prevalent nephrolithiasis. In our study with repeated nephrolithiasis measurements, prevalent renal stones were associated with an altered gut microbiota composition compared to the control. Besides the known oxalate degradation pathway, other functional pathways inferred in this study require further investigation.
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spelling pubmed-89048162022-03-10 Gut microbiota and the prevalence and incidence of renal stones Kim, Han-Na Kim, Jae Heon Chang, Yoosoo Yang, Dongmin Joo, Kwan Joong Cho, Young-Sam Park, Heung Jae Kim, Hyung-Lae Ryu, Seungho Sci Rep Article The role of the gut microbiome in the development of renal stone diseases has not been well characterized. This study focused on the taxonomic and functional profiles of gut microbiomes according to the prevalence and incidence of nephrolithiasis. Stool samples from 915 Korean adults were collected at baseline. Participants were followed for a median of 4.0 years. We evaluated the biodiversity of the gut microbiota and taxonomic profiles associated with nephrolithiasis status, using 16S rRNA gene sequencing. Nephrolithiasis status was categorized into three groups: control (no-stone at both baseline and follow-up visits), incidental nephrolithiasis, and prevalent nephrolithiasis. Compared to the control and incidental nephrolithiasis, the prevalent nephrolithiasis showed a reduced evenness in alpha diversity. Nephrolithiasis was associated with a reduced abundance of some key taxa involved in short-chain fatty acid production. Moreover, the abundance of Bifidobacterium, which possess oxalate-degrading ability, was higher in the control. Conversely, there was no significant difference in the bacterial composition between the incidental and prevalent nephrolithiasis. In our study with repeated nephrolithiasis measurements, prevalent renal stones were associated with an altered gut microbiota composition compared to the control. Besides the known oxalate degradation pathway, other functional pathways inferred in this study require further investigation. Nature Publishing Group UK 2022-03-08 /pmc/articles/PMC8904816/ /pubmed/35260689 http://dx.doi.org/10.1038/s41598-022-07796-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Kim, Han-Na
Kim, Jae Heon
Chang, Yoosoo
Yang, Dongmin
Joo, Kwan Joong
Cho, Young-Sam
Park, Heung Jae
Kim, Hyung-Lae
Ryu, Seungho
Gut microbiota and the prevalence and incidence of renal stones
title Gut microbiota and the prevalence and incidence of renal stones
title_full Gut microbiota and the prevalence and incidence of renal stones
title_fullStr Gut microbiota and the prevalence and incidence of renal stones
title_full_unstemmed Gut microbiota and the prevalence and incidence of renal stones
title_short Gut microbiota and the prevalence and incidence of renal stones
title_sort gut microbiota and the prevalence and incidence of renal stones
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904816/
https://www.ncbi.nlm.nih.gov/pubmed/35260689
http://dx.doi.org/10.1038/s41598-022-07796-y
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