Reduced levels of pulmonary surfactant in COVID-19 ARDS

To provide novel data on surfactant levels in adult COVID-19 patients, we collected bronchoalveolar lavage fluid less than 72 h after intubation and used Fourier Transform Infrared Spectroscopy to measure levels of dipalmitoylphosphatidylcholine (DPPC). A total of eleven COVID-19 patients with moder...

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Detalles Bibliográficos
Autores principales: Schousboe, Peter, Ronit, Andreas, Nielsen, Henning B., Benfield, Thomas, Wiese, Lothar, Scoutaris, Nikolaos, Verder, Henrik, Berg, Ronan M. G., Verder, Povl, Plovsing, Ronni R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904856/
https://www.ncbi.nlm.nih.gov/pubmed/35260704
http://dx.doi.org/10.1038/s41598-022-07944-4
Descripción
Sumario:To provide novel data on surfactant levels in adult COVID-19 patients, we collected bronchoalveolar lavage fluid less than 72 h after intubation and used Fourier Transform Infrared Spectroscopy to measure levels of dipalmitoylphosphatidylcholine (DPPC). A total of eleven COVID-19 patients with moderate-to-severe ARDS (CARDS) and 15 healthy controls were included. CARDS patients had lower DPPC levels than healthy controls. Moreover, a principal component analysis was able to separate patient groups into distinguishable subgroups. Our findings indicate markedly impaired pulmonary surfactant levels in COVID-19 patients, justifying further studies and clinical trials of exogenous surfactant.

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