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Efficient Synthesis of 2,3′-Spirobi (Indolin)-2′-Ones and Preliminary Evaluation of Their Damage to Mitochondria in HeLa Cells

A novel formal (4 + 1) annulation between N-(o-chloromethyl)aryl amides and 3-chlorooxindoles through in situ generated aza-ortho-QMs with 3-chlorooxindoles is reported for the synthesis of a series of 2,3′-spirobi (indolin)-2′-ones in high yields. Under structured illumination microscopy, compound...

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Detalles Bibliográficos
Autores principales: Li, Huajie, Yu, Zhenjie, Sun, Haoyi, Liu, Bo, Wang, Xin, Shao, Zhe, Wang, Meiling, Xie, Weilin, Yao, Xingang, Yao, Qingqiang, Zhi, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904893/
https://www.ncbi.nlm.nih.gov/pubmed/35280257
http://dx.doi.org/10.3389/fphar.2021.821518

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