TP53 promotes lineage commitment of human embryonic stem cells through ciliogenesis and sonic hedgehog signaling

Aneuploidy, defective differentiation, and inactivation of the tumor suppressor TP53 all occur frequently during tumorigenesis. Here, we probe the potential links among these cancer traits by inactivating TP53 in human embryonic stem cells (hESCs). TP53(−/−) hESCs exhibit increased proliferation rat...

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Detalles Bibliográficos
Autores principales: Sivakumar, Sushama, Qi, Shutao, Cheng, Ningyan, Sathe, Adwait A., Kanchwala, Mohammed, Kumar, Ashwani, Evers, Bret M., Xing, Chao, Yu, Hongtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904926/
https://www.ncbi.nlm.nih.gov/pubmed/35172133
http://dx.doi.org/10.1016/j.celrep.2022.110395

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904926/
https://www.ncbi.nlm.nih.gov/pubmed/35172133
http://dx.doi.org/10.1016/j.celrep.2022.110395

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