Cargando…

TP53 promotes lineage commitment of human embryonic stem cells through ciliogenesis and sonic hedgehog signaling

Aneuploidy, defective differentiation, and inactivation of the tumor suppressor TP53 all occur frequently during tumorigenesis. Here, we probe the potential links among these cancer traits by inactivating TP53 in human embryonic stem cells (hESCs). TP53(−/−) hESCs exhibit increased proliferation rat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sivakumar, Sushama, Qi, Shutao, Cheng, Ningyan, Sathe, Adwait A., Kanchwala, Mohammed, Kumar, Ashwani, Evers, Bret M., Xing, Chao, Yu, Hongtao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904926/ https://www.ncbi.nlm.nih.gov/pubmed/35172133 http://dx.doi.org/10.1016/j.celrep.2022.110395

Ejemplares similares

CRISPR-Cas9 screen in human embryonic stem cells to identify genes required for neural differentiation
por: Qi, Shutao, et al.
Publicado: (2022)

STAG2 promotes the myelination transcriptional program in oligodendrocytes
por: Cheng, Ningyan, et al.
Publicado: (2022)

Sonic Hedgehog in SCLC
por: Laukkanen, Mikko O., et al.
Publicado: (2015)

Sonic hedgehog lineage in the mouse hypothalamus: from progenitor domains to hypothalamic regions
por: Alvarez-Bolado, Gonzalo, et al.
Publicado: (2012)

CHD-associated enhancers shape human cardiomyocyte lineage commitment
por: Armendariz, Daniel A, et al.
Publicado: (2023)

Sonic Hedgehog Signaling Is Required for Cyp26 Expression during Embryonic Development
por: El Shahawy, Maha, et al.
Publicado: (2019)

Sonic Hedgehog and Triiodothyronine Pathway Interact in Mouse Embryonic Neural Stem Cells
por: Ostasov, Pavel, et al.
Publicado: (2020)

Genetic drivers of metastatic dissemination in sonic hedgehog medulloblastoma
por: Jenkins, Noah C, et al.
Publicado: (2014)

MBRS-21. CLINICAL AGGRESSIVENESS OF TP53-WILD TYPE SONIC HEDGEHOG MEDULLOBLASTOMA WITH MYCN AMPLIFICATION
por: Mitani, Yuichi, et al.
Publicado: (2020)

Sonic hedgehog signaling in astrocytes
por: Hill, Steven A., et al.
Publicado: (2020)

Cell cycle-related kinase is a crucial regulator for ciliogenesis and Hedgehog signaling in embryonic mouse lung development
por: Lee, Hankyu, et al.
Publicado: (2020)

Inhibitors of Hedgehog Acyltransferase Block Sonic Hedgehog Signaling
por: Petrova, Elissaveta, et al.
Publicado: (2013)

NRF2 negatively regulates primary ciliogenesis and hedgehog signaling
por: Liu, Pengfei, et al.
Publicado: (2020)

A non-canonical Hedgehog pathway initiates ciliogenesis and autophagy
por: Akhshi, Tara, et al.
Publicado: (2020)

Cortical Neural Stem Cell Lineage Progression Is Regulated by Extrinsic Signaling Molecule Sonic Hedgehog
por: Zhang, Yue, et al.
Publicado: (2020)

Thyroid Hormone Regulates the Expression of the Sonic Hedgehog Signaling Pathway in the Embryonic and Adult Mammalian Brain
por: Desouza, Lynette A., et al.
Publicado: (2011)

Effect of sonic hedgehog on motor neuron positioning in the spinal cord during chicken embryonic development
por: Yang, Ciqing, et al.
Publicado: (2019)

Regulation of Thalamic Development by Sonic Hedgehog
por: Epstein, Douglas J.
Publicado: (2012)

Probing extracellular Sonic hedgehog in neurons
por: Eitan, Erez, et al.
Publicado: (2016)

Sonic Hedgehog Signaling in Thyroid Cancer
por: Xu, Xiulong, et al.
Publicado: (2017)

A highlight on Sonic hedgehog pathway
por: Carballo, Gabriela Basile, et al.
Publicado: (2018)

Sonic Hedgehog Signaling and Development of the Dentition
por: Seppala, Maisa, et al.
Publicado: (2017)

Sonic Hedgehog Signaling in Limb Development
por: Tickle, Cheryll, et al.
Publicado: (2017)

Sonic hedgehog expression in the postnatal brain
por: Rivell, Aileen, et al.
Publicado: (2019)

Sonic Hedgehog Signaling and Tooth Development
por: Hosoya, Akihiro, et al.
Publicado: (2020)

The Role of Polycomb Proteins in Cell Lineage Commitment and Embryonic Development
por: Loh, Chet H., et al.
Publicado: (2022)

NRF2-dependent gene expression promotes ciliogenesis and Hedgehog signaling
por: Martin-Hurtado, Ana, et al.
Publicado: (2019)

Sonic hedgehog is a potent chemoattractant for human monocytes: diabetes mellitus inhibits Sonic hedgehog-induced monocyte chemotaxis
por: Dunaeva, Marina, et al.
Publicado: (2009)

Embryonic Ethanol but Not Cannabinoid Exposure Affects Zebrafish Cardiac Development via Agrin and Sonic Hedgehog Interaction
por: Zhang, Chengjin, et al.
Publicado: (2023)

Developmental pathways: Sonic hedgehog-Patched-GLI.
por: Walterhouse, D O, et al.
Publicado: (1999)

Ontogenetic Expression of Sonic Hedgehog in the Chicken Subpallium
por: Bardet, Sylvia M., et al.
Publicado: (2010)

Sonic hedgehog promotes autophagy in hippocampal neurons
por: Petralia, Ronald S., et al.
Publicado: (2013)

Sonic hedgehog signaling in the development of the mouse hypothalamus
por: Blaess, Sandra, et al.
Publicado: (2015)

Sonic Hedgehog: a lipid speciated hormone?
por: Long, Jun, et al.
Publicado: (2015)

Sonic hedgehog signaling in epithelial tissue development
por: Zheng, Lu, et al.
Publicado: (2019)

Sonic Hedgehog Regulates Bone Fracture Healing
por: Takebe, Hiroaki, et al.
Publicado: (2020)

Sonic Hedgehog Signaling in Cerebellar Development and Cancer
por: Wang, Wanchen, et al.
Publicado: (2022)

Sonic Hedgehog: Powering up Intestinal Regeneration?
por: Frey, Mark R.
Publicado: (2023)

Transcriptional analysis of early lineage commitment in human embryonic stem cells
por: Laslett, Andrew L, et al.
Publicado: (2007)

Cell Cycle-Related Kinase (CCRK) regulates ciliogenesis and Hedgehog signaling in mice
por: Snouffer, Ashley, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_dv2utnafbp5gcrcshlalg1tpvu