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Analysis of prognostic and therapeutic values of drug resistance-related genes in the lung cancer microenvironment

BACKGROUND: The interaction between cancer cells and stromal cells has a significant contribution in tumorigenesis and tumor development, and plays an anti-tumor immune effect under the regulation of drug resistance-related genes, which affects the outcome of patients. Coiled-coil domain-containing...

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Autores principales: Zhu, Liang, Chen, Peixin, Wang, Hao, Zhao, Lishu, Guo, Haoyue, Jiang, Minlin, Zhao, Sha, Li, Wei, Zhu, Jun, Yu, Jia, Dai, Jiawei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904958/
https://www.ncbi.nlm.nih.gov/pubmed/35281414
http://dx.doi.org/10.21037/tcr-21-1841
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author Zhu, Liang
Chen, Peixin
Wang, Hao
Zhao, Lishu
Guo, Haoyue
Jiang, Minlin
Zhao, Sha
Li, Wei
Zhu, Jun
Yu, Jia
Dai, Jiawei
author_facet Zhu, Liang
Chen, Peixin
Wang, Hao
Zhao, Lishu
Guo, Haoyue
Jiang, Minlin
Zhao, Sha
Li, Wei
Zhu, Jun
Yu, Jia
Dai, Jiawei
author_sort Zhu, Liang
collection PubMed
description BACKGROUND: The interaction between cancer cells and stromal cells has a significant contribution in tumorigenesis and tumor development, and plays an anti-tumor immune effect under the regulation of drug resistance-related genes, which affects the outcome of patients. Coiled-coil domain-containing protein 73 (CCDC73), DLG associated protein 1 (DLGAP1), dermatan sulfate epimerase like (DSEL), estrogen receptor 1 (ESR1), and SEC14-like 5 (SEC14L5) were identified as drug resistance-related genes in lung cancer. However, these genes have no clear value in lung cancer in terms of expression and prognosis. METHODS: ONCOMINE, GEPIA, UALCAN, cBioPortal, GeneMANIA, STRING, and TIMER were utilized in this study. RESULTS: The transcriptional expression level of DLGAP1 was remarkably decreased in lung cancer tissues, while the transcriptional level of SEC14L5 was significantly increased. The pathological stage of lung adenocarcinoma (LUAD) was tightly correlated with the expression of SEC14L5. The lung cancer patients with high transcription level of CCDC73 gene tended to have a good prognosis. The function of drug resistance-related genes is mainly related to RNA polymerization. Our results showed that infiltration of six types of immune cells (dendritic cells, macrophages, neutrophils, B cells, CD4(+) T cells, and CD8(+) T cells) significantly correlated with the expression of these drug resistance-related genes. CONCLUSIONS: Novel screening for immunotherapy targets and prognostic biomarkers in lung cancer may draw inspiration from our results.
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spelling pubmed-89049582022-03-10 Analysis of prognostic and therapeutic values of drug resistance-related genes in the lung cancer microenvironment Zhu, Liang Chen, Peixin Wang, Hao Zhao, Lishu Guo, Haoyue Jiang, Minlin Zhao, Sha Li, Wei Zhu, Jun Yu, Jia Dai, Jiawei Transl Cancer Res Original Article BACKGROUND: The interaction between cancer cells and stromal cells has a significant contribution in tumorigenesis and tumor development, and plays an anti-tumor immune effect under the regulation of drug resistance-related genes, which affects the outcome of patients. Coiled-coil domain-containing protein 73 (CCDC73), DLG associated protein 1 (DLGAP1), dermatan sulfate epimerase like (DSEL), estrogen receptor 1 (ESR1), and SEC14-like 5 (SEC14L5) were identified as drug resistance-related genes in lung cancer. However, these genes have no clear value in lung cancer in terms of expression and prognosis. METHODS: ONCOMINE, GEPIA, UALCAN, cBioPortal, GeneMANIA, STRING, and TIMER were utilized in this study. RESULTS: The transcriptional expression level of DLGAP1 was remarkably decreased in lung cancer tissues, while the transcriptional level of SEC14L5 was significantly increased. The pathological stage of lung adenocarcinoma (LUAD) was tightly correlated with the expression of SEC14L5. The lung cancer patients with high transcription level of CCDC73 gene tended to have a good prognosis. The function of drug resistance-related genes is mainly related to RNA polymerization. Our results showed that infiltration of six types of immune cells (dendritic cells, macrophages, neutrophils, B cells, CD4(+) T cells, and CD8(+) T cells) significantly correlated with the expression of these drug resistance-related genes. CONCLUSIONS: Novel screening for immunotherapy targets and prognostic biomarkers in lung cancer may draw inspiration from our results. AME Publishing Company 2022-02 /pmc/articles/PMC8904958/ /pubmed/35281414 http://dx.doi.org/10.21037/tcr-21-1841 Text en 2022 Translational Cancer Research. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.
spellingShingle Original Article
Zhu, Liang
Chen, Peixin
Wang, Hao
Zhao, Lishu
Guo, Haoyue
Jiang, Minlin
Zhao, Sha
Li, Wei
Zhu, Jun
Yu, Jia
Dai, Jiawei
Analysis of prognostic and therapeutic values of drug resistance-related genes in the lung cancer microenvironment
title Analysis of prognostic and therapeutic values of drug resistance-related genes in the lung cancer microenvironment
title_full Analysis of prognostic and therapeutic values of drug resistance-related genes in the lung cancer microenvironment
title_fullStr Analysis of prognostic and therapeutic values of drug resistance-related genes in the lung cancer microenvironment
title_full_unstemmed Analysis of prognostic and therapeutic values of drug resistance-related genes in the lung cancer microenvironment
title_short Analysis of prognostic and therapeutic values of drug resistance-related genes in the lung cancer microenvironment
title_sort analysis of prognostic and therapeutic values of drug resistance-related genes in the lung cancer microenvironment
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904958/
https://www.ncbi.nlm.nih.gov/pubmed/35281414
http://dx.doi.org/10.21037/tcr-21-1841
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