Cargando…

Connective tissue growth factor expression hints at aggressive nature of colorectal cancer

BACKGROUND: Connective tissue growth factor (CTGF) is a mediator of transforming growth factor-beta signaling and plays a key role in connective tissue remodeling, inflammatory processes and fibrosis in various illnesses including cancer. AIM: To investigate the role of CTGF in colorectal cancer (CR...

Descripción completa

Detalles Bibliográficos
Autores principales: Bhat, Ishrat Parveiz, Rather, Tahseen Bilal, Maqbool, Irfan, Rashid, Gowhar, Akhtar, Kulsum, Bhat, Gulzar A, Parray, Fazl Q, Syed, Besina, Khan, Ishrat Younas, Kazi, Mohsin, Hussain, Muhammad D, Syed, Mudassar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8905019/
https://www.ncbi.nlm.nih.gov/pubmed/35316957
http://dx.doi.org/10.3748/wjg.v28.i5.547
_version_ 1784665090201485312
author Bhat, Ishrat Parveiz
Rather, Tahseen Bilal
Maqbool, Irfan
Rashid, Gowhar
Akhtar, Kulsum
Bhat, Gulzar A
Parray, Fazl Q
Syed, Besina
Khan, Ishrat Younas
Kazi, Mohsin
Hussain, Muhammad D
Syed, Mudassar
author_facet Bhat, Ishrat Parveiz
Rather, Tahseen Bilal
Maqbool, Irfan
Rashid, Gowhar
Akhtar, Kulsum
Bhat, Gulzar A
Parray, Fazl Q
Syed, Besina
Khan, Ishrat Younas
Kazi, Mohsin
Hussain, Muhammad D
Syed, Mudassar
author_sort Bhat, Ishrat Parveiz
collection PubMed
description BACKGROUND: Connective tissue growth factor (CTGF) is a mediator of transforming growth factor-beta signaling and plays a key role in connective tissue remodeling, inflammatory processes and fibrosis in various illnesses including cancer. AIM: To investigate the role of CTGF in colorectal cancer (CRC) progression and to compare the CTGF expression with different clinicopathological parameters. METHODS: Real-time polymerase chain reaction, immunohistochemistry and Western blotting was performed to evaluate the CTGF expression and the results were statistically analyzed against the clinicopathological variables of patient data using STATA software version 16. RESULTS: CTGF expression levels in tumor specimens were significantly higher than their paired normal specimens. The higher protein expression levels showed a significant association with smoking, staging, tumor grade, invasion depth, necrosis of tumor tissue, and both lymphovascular and perineural invasion. As per the cox regression model and classification tree analysis, tumor-node-metastasis stage and perineural invasion were important predictors for CTGF expression and prognosis of CRC patients. Survival analysis indicated that CTGF overexpression was associated with poorer overall and disease-free survival. CONCLUSION: Expression of CTGF was increased in CRC and was linked with poor overall and disease-free survival of CRC patients. These findings support prior observations and thus CTGF may be a possible prognostic marker in CRC.
format Online
Article
Text
id pubmed-8905019
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Baishideng Publishing Group Inc
record_format MEDLINE/PubMed
spelling pubmed-89050192022-03-21 Connective tissue growth factor expression hints at aggressive nature of colorectal cancer Bhat, Ishrat Parveiz Rather, Tahseen Bilal Maqbool, Irfan Rashid, Gowhar Akhtar, Kulsum Bhat, Gulzar A Parray, Fazl Q Syed, Besina Khan, Ishrat Younas Kazi, Mohsin Hussain, Muhammad D Syed, Mudassar World J Gastroenterol Basic Study BACKGROUND: Connective tissue growth factor (CTGF) is a mediator of transforming growth factor-beta signaling and plays a key role in connective tissue remodeling, inflammatory processes and fibrosis in various illnesses including cancer. AIM: To investigate the role of CTGF in colorectal cancer (CRC) progression and to compare the CTGF expression with different clinicopathological parameters. METHODS: Real-time polymerase chain reaction, immunohistochemistry and Western blotting was performed to evaluate the CTGF expression and the results were statistically analyzed against the clinicopathological variables of patient data using STATA software version 16. RESULTS: CTGF expression levels in tumor specimens were significantly higher than their paired normal specimens. The higher protein expression levels showed a significant association with smoking, staging, tumor grade, invasion depth, necrosis of tumor tissue, and both lymphovascular and perineural invasion. As per the cox regression model and classification tree analysis, tumor-node-metastasis stage and perineural invasion were important predictors for CTGF expression and prognosis of CRC patients. Survival analysis indicated that CTGF overexpression was associated with poorer overall and disease-free survival. CONCLUSION: Expression of CTGF was increased in CRC and was linked with poor overall and disease-free survival of CRC patients. These findings support prior observations and thus CTGF may be a possible prognostic marker in CRC. Baishideng Publishing Group Inc 2022-02-07 2022-02-07 /pmc/articles/PMC8905019/ /pubmed/35316957 http://dx.doi.org/10.3748/wjg.v28.i5.547 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Basic Study
Bhat, Ishrat Parveiz
Rather, Tahseen Bilal
Maqbool, Irfan
Rashid, Gowhar
Akhtar, Kulsum
Bhat, Gulzar A
Parray, Fazl Q
Syed, Besina
Khan, Ishrat Younas
Kazi, Mohsin
Hussain, Muhammad D
Syed, Mudassar
Connective tissue growth factor expression hints at aggressive nature of colorectal cancer
title Connective tissue growth factor expression hints at aggressive nature of colorectal cancer
title_full Connective tissue growth factor expression hints at aggressive nature of colorectal cancer
title_fullStr Connective tissue growth factor expression hints at aggressive nature of colorectal cancer
title_full_unstemmed Connective tissue growth factor expression hints at aggressive nature of colorectal cancer
title_short Connective tissue growth factor expression hints at aggressive nature of colorectal cancer
title_sort connective tissue growth factor expression hints at aggressive nature of colorectal cancer
topic Basic Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8905019/
https://www.ncbi.nlm.nih.gov/pubmed/35316957
http://dx.doi.org/10.3748/wjg.v28.i5.547
work_keys_str_mv AT bhatishratparveiz connectivetissuegrowthfactorexpressionhintsataggressivenatureofcolorectalcancer
AT rathertahseenbilal connectivetissuegrowthfactorexpressionhintsataggressivenatureofcolorectalcancer
AT maqboolirfan connectivetissuegrowthfactorexpressionhintsataggressivenatureofcolorectalcancer
AT rashidgowhar connectivetissuegrowthfactorexpressionhintsataggressivenatureofcolorectalcancer
AT akhtarkulsum connectivetissuegrowthfactorexpressionhintsataggressivenatureofcolorectalcancer
AT bhatgulzara connectivetissuegrowthfactorexpressionhintsataggressivenatureofcolorectalcancer
AT parrayfazlq connectivetissuegrowthfactorexpressionhintsataggressivenatureofcolorectalcancer
AT syedbesina connectivetissuegrowthfactorexpressionhintsataggressivenatureofcolorectalcancer
AT khanishratyounas connectivetissuegrowthfactorexpressionhintsataggressivenatureofcolorectalcancer
AT kazimohsin connectivetissuegrowthfactorexpressionhintsataggressivenatureofcolorectalcancer
AT hussainmuhammadd connectivetissuegrowthfactorexpressionhintsataggressivenatureofcolorectalcancer
AT syedmudassar connectivetissuegrowthfactorexpressionhintsataggressivenatureofcolorectalcancer