Extreme Thrombocytosis in Refractory ITP Post-Splenectomy With Associated Fatal Thromboembolism

Thrombopoietin (TPO)-receptor agonists have heralded a paradigm shift in the treatment of refractory immune thrombocytopenia (ITP). Reactive thrombocytosis has been described as a secondary effect of such therapies. However, the phenomenon of extreme thrombocytosis with morphology mimicking a myelop...

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Autores principales: Nedumannil, Rithin, Leitinger, Emma, Juneja, Surender
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8905198/
https://www.ncbi.nlm.nih.gov/pubmed/35284824
http://dx.doi.org/10.1177/2632010X221083218
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author Nedumannil, Rithin
Leitinger, Emma
Juneja, Surender
author_facet Nedumannil, Rithin
Leitinger, Emma
Juneja, Surender
author_sort Nedumannil, Rithin
collection PubMed
description Thrombopoietin (TPO)-receptor agonists have heralded a paradigm shift in the treatment of refractory immune thrombocytopenia (ITP). Reactive thrombocytosis has been described as a secondary effect of such therapies. However, the phenomenon of extreme thrombocytosis with morphology mimicking a myeloproliferative neoplasm (MPN) followed by fatal thromboembolism is unusual in this setting. Caution is required in the diagnosis of refractory ITP as well as TPO-receptor agonist dosing in such cases.
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spelling pubmed-89051982022-03-10 Extreme Thrombocytosis in Refractory ITP Post-Splenectomy With Associated Fatal Thromboembolism Nedumannil, Rithin Leitinger, Emma Juneja, Surender Clin Pathol Case Report Thrombopoietin (TPO)-receptor agonists have heralded a paradigm shift in the treatment of refractory immune thrombocytopenia (ITP). Reactive thrombocytosis has been described as a secondary effect of such therapies. However, the phenomenon of extreme thrombocytosis with morphology mimicking a myeloproliferative neoplasm (MPN) followed by fatal thromboembolism is unusual in this setting. Caution is required in the diagnosis of refractory ITP as well as TPO-receptor agonist dosing in such cases. SAGE Publications 2022-03-04 /pmc/articles/PMC8905198/ /pubmed/35284824 http://dx.doi.org/10.1177/2632010X221083218 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Nedumannil, Rithin
Leitinger, Emma
Juneja, Surender
Extreme Thrombocytosis in Refractory ITP Post-Splenectomy With Associated Fatal Thromboembolism
title Extreme Thrombocytosis in Refractory ITP Post-Splenectomy With Associated Fatal Thromboembolism
title_full Extreme Thrombocytosis in Refractory ITP Post-Splenectomy With Associated Fatal Thromboembolism
title_fullStr Extreme Thrombocytosis in Refractory ITP Post-Splenectomy With Associated Fatal Thromboembolism
title_full_unstemmed Extreme Thrombocytosis in Refractory ITP Post-Splenectomy With Associated Fatal Thromboembolism
title_short Extreme Thrombocytosis in Refractory ITP Post-Splenectomy With Associated Fatal Thromboembolism
title_sort extreme thrombocytosis in refractory itp post-splenectomy with associated fatal thromboembolism
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8905198/
https://www.ncbi.nlm.nih.gov/pubmed/35284824
http://dx.doi.org/10.1177/2632010X221083218
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