Cargando…
Cardiovascular disturbances in COVID-19: an updated review of the pathophysiology and clinical evidence of cardiovascular damage induced by SARS-CoV-2
Severe acute respiratory coronavirus-2 (SARS-Co-2) is the causative agent of coronavirus disease-2019 (COVID-19). COVID-19 is a disease with highly variable phenotypes, being asymptomatic in most patients. In symptomatic patients, disease manifestation is variable, ranging from mild disease to sever...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8905284/ https://www.ncbi.nlm.nih.gov/pubmed/35264107 http://dx.doi.org/10.1186/s12872-022-02534-8 |
_version_ | 1784665151523258368 |
---|---|
author | Lawal, Ismaheel O. Kgatle, Mankgopo M. Mokoala, Kgomotso Farate, Abubakar Sathekge, Mike M. |
author_facet | Lawal, Ismaheel O. Kgatle, Mankgopo M. Mokoala, Kgomotso Farate, Abubakar Sathekge, Mike M. |
author_sort | Lawal, Ismaheel O. |
collection | PubMed |
description | Severe acute respiratory coronavirus-2 (SARS-Co-2) is the causative agent of coronavirus disease-2019 (COVID-19). COVID-19 is a disease with highly variable phenotypes, being asymptomatic in most patients. In symptomatic patients, disease manifestation is variable, ranging from mild disease to severe and critical illness requiring treatment in the intensive care unit. The presence of underlying cardiovascular morbidities was identified early in the evolution of the disease to be a critical determinant of the severe disease phenotype. SARS-CoV-2, though a primarily respiratory virus, also causes severe damage to the cardiovascular system, contributing significantly to morbidity and mortality seen in COVID-19. Evidence on the impact of cardiovascular disorders in disease manifestation and outcome of treatment is rapidly emerging. The cardiovascular system expresses the angiotensin-converting enzyme-2, the receptor used by SARS-CoV-2 for binding, making it vulnerable to infection by the virus. Systemic perturbations including the so-called cytokine storm also impact on the normal functioning of the cardiovascular system. Imaging plays a prominent role not only in the detection of cardiovascular damage induced by SARS-CoV-2 infection but in the follow-up of patients’ clinical progress while on treatment and in identifying long-term sequelae of the disease. |
format | Online Article Text |
id | pubmed-8905284 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-89052842022-03-09 Cardiovascular disturbances in COVID-19: an updated review of the pathophysiology and clinical evidence of cardiovascular damage induced by SARS-CoV-2 Lawal, Ismaheel O. Kgatle, Mankgopo M. Mokoala, Kgomotso Farate, Abubakar Sathekge, Mike M. BMC Cardiovasc Disord Review Severe acute respiratory coronavirus-2 (SARS-Co-2) is the causative agent of coronavirus disease-2019 (COVID-19). COVID-19 is a disease with highly variable phenotypes, being asymptomatic in most patients. In symptomatic patients, disease manifestation is variable, ranging from mild disease to severe and critical illness requiring treatment in the intensive care unit. The presence of underlying cardiovascular morbidities was identified early in the evolution of the disease to be a critical determinant of the severe disease phenotype. SARS-CoV-2, though a primarily respiratory virus, also causes severe damage to the cardiovascular system, contributing significantly to morbidity and mortality seen in COVID-19. Evidence on the impact of cardiovascular disorders in disease manifestation and outcome of treatment is rapidly emerging. The cardiovascular system expresses the angiotensin-converting enzyme-2, the receptor used by SARS-CoV-2 for binding, making it vulnerable to infection by the virus. Systemic perturbations including the so-called cytokine storm also impact on the normal functioning of the cardiovascular system. Imaging plays a prominent role not only in the detection of cardiovascular damage induced by SARS-CoV-2 infection but in the follow-up of patients’ clinical progress while on treatment and in identifying long-term sequelae of the disease. BioMed Central 2022-03-09 /pmc/articles/PMC8905284/ /pubmed/35264107 http://dx.doi.org/10.1186/s12872-022-02534-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Lawal, Ismaheel O. Kgatle, Mankgopo M. Mokoala, Kgomotso Farate, Abubakar Sathekge, Mike M. Cardiovascular disturbances in COVID-19: an updated review of the pathophysiology and clinical evidence of cardiovascular damage induced by SARS-CoV-2 |
title | Cardiovascular disturbances in COVID-19: an updated review of the pathophysiology and clinical evidence of cardiovascular damage induced by SARS-CoV-2 |
title_full | Cardiovascular disturbances in COVID-19: an updated review of the pathophysiology and clinical evidence of cardiovascular damage induced by SARS-CoV-2 |
title_fullStr | Cardiovascular disturbances in COVID-19: an updated review of the pathophysiology and clinical evidence of cardiovascular damage induced by SARS-CoV-2 |
title_full_unstemmed | Cardiovascular disturbances in COVID-19: an updated review of the pathophysiology and clinical evidence of cardiovascular damage induced by SARS-CoV-2 |
title_short | Cardiovascular disturbances in COVID-19: an updated review of the pathophysiology and clinical evidence of cardiovascular damage induced by SARS-CoV-2 |
title_sort | cardiovascular disturbances in covid-19: an updated review of the pathophysiology and clinical evidence of cardiovascular damage induced by sars-cov-2 |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8905284/ https://www.ncbi.nlm.nih.gov/pubmed/35264107 http://dx.doi.org/10.1186/s12872-022-02534-8 |
work_keys_str_mv | AT lawalismaheelo cardiovasculardisturbancesincovid19anupdatedreviewofthepathophysiologyandclinicalevidenceofcardiovasculardamageinducedbysarscov2 AT kgatlemankgopom cardiovasculardisturbancesincovid19anupdatedreviewofthepathophysiologyandclinicalevidenceofcardiovasculardamageinducedbysarscov2 AT mokoalakgomotso cardiovasculardisturbancesincovid19anupdatedreviewofthepathophysiologyandclinicalevidenceofcardiovasculardamageinducedbysarscov2 AT farateabubakar cardiovasculardisturbancesincovid19anupdatedreviewofthepathophysiologyandclinicalevidenceofcardiovasculardamageinducedbysarscov2 AT sathekgemikem cardiovasculardisturbancesincovid19anupdatedreviewofthepathophysiologyandclinicalevidenceofcardiovasculardamageinducedbysarscov2 |