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Differences in potential key genes and pathways between primary and radiation-associated angiosarcoma of the breast
BACKGROUND: Angiosarcoma of the breast is a high-grade malignant soft tissue tumor, it can be divided into primary and radiation-associated angiosarcoma(secondary). However, the differences between primary and secondary angiosarcomas in terms of pathogenesis, clinical behavior, early diagnosis bioma...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Neoplasia Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8905315/ https://www.ncbi.nlm.nih.gov/pubmed/35263699 http://dx.doi.org/10.1016/j.tranon.2022.101385 |
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author | Wei, Yuanfeng Yang, Xi Gao, Limin Xu, Yong Yi, Cheng |
author_facet | Wei, Yuanfeng Yang, Xi Gao, Limin Xu, Yong Yi, Cheng |
author_sort | Wei, Yuanfeng |
collection | PubMed |
description | BACKGROUND: Angiosarcoma of the breast is a high-grade malignant soft tissue tumor, it can be divided into primary and radiation-associated angiosarcoma(secondary). However, the differences between primary and secondary angiosarcomas in terms of pathogenesis, clinical behavior, early diagnosis biomarkers, genetic abnormalities, and therapeutic targets remain to be fully elucidated. At the same time, due to its rarity, most of current information relating to angiosarcoma is provided by case reports. Therefore, exploring the mechanisms of primary and secondary breast angiosarcoma have important value for the discovery of new biomarkers and research into potential therapeutic targets. METHODS: The differentially expressed genes (DEGs) between 36 cases of primary angiosarcoma and 54 cases of secondary angiosarcoma were screened. Then, the DEGs were used to gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. Then, a protein-protein interaction (PPI) network was constructed using the STRING database. RESULTS: A total of 18 DEGs were identified, of which 13 were upregulated and 5 were downregulated in secondary breast angiosarcoma. The GO enrichment analysis showed that the DEGs were most enriched in metabolism, energy pathways, and protein metabolism in biological processes. The enriched signaling pathways of DEGs were the transforming growth factor-β (TGF-β), Wnt, Hippo and PI3K-Akt signaling pathways. Then, the PPI network was conducted and hub genes were identified and they were involved in thyroid hormone, Hippo and other signaling pathways. CONCLUSION: This study lay the foundation for the discovery of effective and reliable molecular biomarkers and essential therapeutic targets for these malignancies. |
format | Online Article Text |
id | pubmed-8905315 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Neoplasia Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-89053152022-03-21 Differences in potential key genes and pathways between primary and radiation-associated angiosarcoma of the breast Wei, Yuanfeng Yang, Xi Gao, Limin Xu, Yong Yi, Cheng Transl Oncol Original Research BACKGROUND: Angiosarcoma of the breast is a high-grade malignant soft tissue tumor, it can be divided into primary and radiation-associated angiosarcoma(secondary). However, the differences between primary and secondary angiosarcomas in terms of pathogenesis, clinical behavior, early diagnosis biomarkers, genetic abnormalities, and therapeutic targets remain to be fully elucidated. At the same time, due to its rarity, most of current information relating to angiosarcoma is provided by case reports. Therefore, exploring the mechanisms of primary and secondary breast angiosarcoma have important value for the discovery of new biomarkers and research into potential therapeutic targets. METHODS: The differentially expressed genes (DEGs) between 36 cases of primary angiosarcoma and 54 cases of secondary angiosarcoma were screened. Then, the DEGs were used to gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. Then, a protein-protein interaction (PPI) network was constructed using the STRING database. RESULTS: A total of 18 DEGs were identified, of which 13 were upregulated and 5 were downregulated in secondary breast angiosarcoma. The GO enrichment analysis showed that the DEGs were most enriched in metabolism, energy pathways, and protein metabolism in biological processes. The enriched signaling pathways of DEGs were the transforming growth factor-β (TGF-β), Wnt, Hippo and PI3K-Akt signaling pathways. Then, the PPI network was conducted and hub genes were identified and they were involved in thyroid hormone, Hippo and other signaling pathways. CONCLUSION: This study lay the foundation for the discovery of effective and reliable molecular biomarkers and essential therapeutic targets for these malignancies. Neoplasia Press 2022-03-06 /pmc/articles/PMC8905315/ /pubmed/35263699 http://dx.doi.org/10.1016/j.tranon.2022.101385 Text en © 2022 The Authors. Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Research Wei, Yuanfeng Yang, Xi Gao, Limin Xu, Yong Yi, Cheng Differences in potential key genes and pathways between primary and radiation-associated angiosarcoma of the breast |
title | Differences in potential key genes and pathways between primary and radiation-associated angiosarcoma of the breast |
title_full | Differences in potential key genes and pathways between primary and radiation-associated angiosarcoma of the breast |
title_fullStr | Differences in potential key genes and pathways between primary and radiation-associated angiosarcoma of the breast |
title_full_unstemmed | Differences in potential key genes and pathways between primary and radiation-associated angiosarcoma of the breast |
title_short | Differences in potential key genes and pathways between primary and radiation-associated angiosarcoma of the breast |
title_sort | differences in potential key genes and pathways between primary and radiation-associated angiosarcoma of the breast |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8905315/ https://www.ncbi.nlm.nih.gov/pubmed/35263699 http://dx.doi.org/10.1016/j.tranon.2022.101385 |
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